Journal ArticleDOI
Antifungal drug resistance of pathogenic fungi
Reads0
Chats0
TLDR
This work critically review the diagnosis, epidemiology, and mechanisms of antifungal drug resistance of pathogenic fungi, and proposes strategies for preventing and treating refractory mycoses in the future.About:
This article is published in The Lancet.The article was published on 2002-03-30. It has received 400 citations till now. The article focuses on the topics: Antifungal drug & Fungal genetics.read more
Citations
More filters
Journal ArticleDOI
Transcriptional Response of Candida albicans upon Internalization by Macrophages
TL;DR: This analysis reveals a dramatic reprogramming of transcription in C. albicans that occurs in two successive steps, suggesting that these large-scale and coordinated changes contribute significantly to the ability of this organism to survive and cause disease in vivo.
Journal ArticleDOI
Zygomycosis in a Tertiary-Care Cancer Center in the Era of Aspergillus-Active Antifungal Therapy: A Case-Control Observational Study of 27 Recent Cases
Dimitrios P. Kontoyiannis,Michail S. Lionakis,Russell E. Lewis,Russell E. Lewis,Georgios Chamilos,Mimi Healy,Cheryl Perego,Amar Safdar,Hagop M. Kantarjian,Richard E. Champlin,Thomas J. Walsh,Issam I Raad +11 more
TL;DR: Zygomycosis should be considered in immunosuppressed patients who develop sinusitis while receiving VRC prophylaxis, especially those with diabetes and malnutrition.
Journal ArticleDOI
Efflux-Mediated Antifungal Drug Resistance
Richard D. Cannon,Erwin Lamping,Ann R. Holmes,Kyoko Niimi,Philippe Baret,Mikhail V. Keniya,Koichi Tanabe,Masakazu Niimi,André Goffeau,Brian C. Monk +9 more
TL;DR: Phylogenetic analysis of the ABC pleiotropic drug resistance family has provided a new view of the evolution of this important class of efflux pumps, and potential therapeutic approaches that could overcome azole resistance are proposed.
Journal ArticleDOI
Current Concepts in Antifungal Pharmacology
TL;DR: Key pharmacological aspects of systemic antifungal agents as well as evolving strategies, such as pharmacokinetic-pharmacodynamic optimization and therapeutic drug monitoring, are reviewed to improve the safety and efficacy of systemic anti-fungal therapy.
References
More filters
Journal ArticleDOI
Aspergillus fumigatus and Aspergillosis
TL;DR: This review focuses on the biology of A. fumigatus, one of the most ubiquitous of the airborne saprophytic fungi, and the diseases it causes, and discusses discussions of genomic and molecular characterization of the organism.
Aspergillus fumigatus and aspergillosis.
TL;DR: A review of the biology of Aspergillus fumigatus and the diseases it causes can be found in this article, where the authors discuss genomic and molecular characterization of the organism, clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunOCompromised hosts, identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and problems associated with antifungal therapy.
Journal ArticleDOI
Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance
TL;DR: The mode of action of antifungals and their mechanisms of resistance are discussed, and an attempt is made to discuss the correlation between fungal and bacterial resistance.