Journal ArticleDOI
Antifungal Phenols from Woodfordia uniflora Collected in Oman
TLDR
Phytochemical screening of the extract of W. uniflora found three new phenolic compounds, including woodfordiamycin, woodfordic acid, and rhamnetin 3-O-(6″-galloyl)-β-d-glucopyranoside, which showed antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans.Abstract:
Woodfordia uniflora is a flowering shrub unique to the Dhofar region of Oman and is used locally as a sedative and remedy for skin infection. However, no study to date has examined the pharmacological properties of this plant, and studies regarding phytochemicals present in W. uniflora are limited. Herein, phytochemical screening of the extract of W. uniflora was performed using LC/MS. Three new phenolic compounds, (±)-woodfordiamycin (1), woodfordic acid (2), and rhamnetin 3-O-(6″-galloyl)-β-d-glucopyranoside (3), together with 16 known compounds 4-19, were isolated from the antifungal fraction of the extract. The structures of the new compounds were established by NMR and HR-MS data, and their absolute configurations were established using chemical transformations, including Mosher's method, comparison of experimental and calculated electronic circular dichroism data, and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4+ analysis. The isolated compounds (1-19) were tested for antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans. Compounds (±)-1 and 8 showed antifungal activity against C. neoformans, with the lowest minimum inhibitory concentrations of 1.8-1.9 μM, which was ∼10-fold lower than that of the currently available antifungal drug fluconazole, while (±)-1, 8, and 19 showed antifungal activity against C. albicans.read more
Citations
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Journal ArticleDOI
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide
TL;DR: In this paper, the authors present a critical revision on how the scientific community has been using DP4+, exploring the strengths of the method and how to obtain optimal results from it.
Journal ArticleDOI
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide
TL;DR: In this article , the authors present a critical revision on how the scientific community has been using DP4+, exploring the strengths of the method and how to obtain optimal results from it.
Journal ArticleDOI
Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba
Kwang Ho Lee,Jung Kyu Kim,Jae Sik Yu,Se Yun Jeong,Jin Hee Choi,Jin-Chul Kim,Yoon-Joo Ko,Seon-Hee Kim,Ki Hyun Kim +8 more
TL;DR: In this paper, two new coumaric acid-aliphatic alcohol hybrids, ginkwanghols A (1) and B (2), were isolated from the leaves of G. biloba.
Journal ArticleDOI
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
TL;DR: In this paper , withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity.
Journal ArticleDOI
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
Weina Meng,Seoung Rak Lee,Seoung Rak Lee,Bum Soo Lee,Jae Sik Yu,Heesun Kang,Min Jeong Yoo,Sang Ah Yi,Jeung Whan Han,Sil Kim,Jung Kyu Kim,Jin-Chul Kim,Ki-Hyun Kim +12 more
TL;DR: In this article, withania somnifera (Solanaceae), generally known as Indian ginseng, is a medicinal plant that is used in Ayurvedic practice for promoting health and longevity.
References
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Assigning Stereochemistry to Single Diastereoisomers by GIAO NMR Calculation: The DP4 Probability
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