Journal ArticleDOI
Antihelminthic activity of some newly synthesized 5(6)-(un)substituted-1H-benzimidazol-2-ylthioacetylpiperazine derivatives.
Anelia Ts. Mavrova,Kamelya K. Anichina,Dimitar Vuchev,J. A. Tsenov,Pavletta Denkova,Magdalena S. Kondeva,Mitka K. Micheva +6 more
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TLDR
The antiparasitic screening showed that compounds 18-24 exhibited higher activity against Trichinella spiralis in vitro in comparison to methyl 5-(propylthio)-1H-benzimidazol-2-yl-carbamate (albendazole).About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2006-12-01. It has received 118 citations till now. The article focuses on the topics: Thio- & Piperazine.read more
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Journal ArticleDOI
Studies of iron corrosion inhibition using chemical, electrochemical and computer simulation techniques
K.F. Khaled,K.F. Khaled +1 more
TL;DR: In this article, the effectiveness of some benzimidazole derivatives against the corrosion of iron in solutions of nitric acid has been studied using density function theory calculations (DFT), weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS).
Journal ArticleDOI
Benzimidazole: a medicinally important heterocyclic moiety
TL;DR: Researchers have synthesized variety of benzimidazole derivatives and screened them for their various biological activities, viz., anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimycobacterial, antihypertensive, pro-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagULant, antioxidant as well antidiabetic activities.
Journal ArticleDOI
Benzimidazoles: A biologically active compounds
TL;DR: The benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc. as mentioned in this paper, which is a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs.
Book ChapterDOI
Synthesis, Reactivity and Biological Activity of Benzimidazoles
TL;DR: Benzimidazole is a biologically important scaffold which displays important biological activities, such as anti-infective, anti-inflammatory, antitumor and receptor agonist/antagonist activities.
Journal ArticleDOI
Nano ceria catalyzed synthesis of substituted benzimidazole, benzothiazole, and benzoxazole in aqueous media
TL;DR: A series of substituted benzimidazoles, benzothiazoles, and benzoxazoles was synthesized by combining 1,2-phenylenediamine, 2-aminothiophenol, or 2 -aminophenol with aryl, heteroaryl, aliphatic, α,β-unsaturated aldehydes in the presence of nano ceria (CeO2) as an efficient heterogeneous catalyst.
References
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Book
Trichinella and Trichinosis
TL;DR: This review focuses on the part of the Gastrointestinal Phase of the Larva-Parasite Interrelationships that concerns Migration of the First-Stage Larva to the Niche and the Influence of Lamina Propria.
Journal Article
Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.
Daniel Fau,D Eugene,Alain Berson,Philippe Lettéron,Bernard Fromenty,C Fisch,Dominique Pessayre +6 more
TL;DR: Flutamide is toxic to rat hepatocytes as a result of the cytochrome P450 (3A and also 1A)-mediated formation of electrophilic metabolites, whose damaging effects are further aggravated by the inhibitory effect of flutamide on mitochondrial respiration and ATP formation.
Journal ArticleDOI
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.
TL;DR: These enzymes exhibit features that differ significantly between the parasites and the human host so it is conceivable that exploitation of such differences can lead to the design of new inhibitors that will selectively kill the parasites while exerting minimal, or at least tolerable, effects on the parasite-infected patient.
Journal ArticleDOI
Synthesis and antitrichinellosis activity of some 2-substituted-[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-ones
Anelia Ts. Mavrova,Kamelya K. Anichina,Dimitar Vuchev,J. A. Tsenov,Magdalena S. Kondeva,Mitka K. Micheva +5 more
TL;DR: The results of the hepatot toxicity test showed that the compounds 4a and 4b possess hepatotoxicity comparable to that of albendazole.