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Antimicrobial peptide arrays for wide spectrum sensing of pathogenic bacteria

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TLDR
Evidence is established that antimicrobial peptides, mostly used so far in the antibiotic drug industry, are suited for the wide-spectrum detection of unknown bacteria in samples, even at very low initial loads.
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This article is published in Talanta.The article was published on 2019-10-01 and is currently open access. It has received 20 citations till now. The article focuses on the topics: Antimicrobial peptides.

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Journal ArticleDOI

Infrared Metasurface Augmented by Deep Learning for Monitoring Dynamics between All Major Classes of Biomolecules.

TL;DR: In this paper, a deep learning-augmented, chemically-specific nanoplasmonic technique that enables such a feat in a label-free manner to not disrupt native processes is presented.
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Surface plasmon resonance based biomimetic sensor for urinary tract infections.

TL;DR: Tailor-made Escherichia coli receptors were created with microcontact imprinted technique and binding events of E. coli were carried out by a surface plasmon resonance (SPR) sensor in aqueous solution and in urine mimic in real time and label-free.
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Antimicrobial Peptides as Probes in Biosensors Detecting Whole Bacteria: A Review.

TL;DR: The state of the art of AMPs used as the recognition elements of whole bacteria in label-free biosensors with a particular focus on the characteristics obtained in terms of threshold, volume of sample analysable and medium are focused on in order to assess their workability in real-world applications.
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Immunoassay Biosensing of Foodborne Pathogens with Surface Plasmon Resonance Imaging: A Review.

TL;DR: The challenges in multiplex detections of foodborne pathogens in real-world samples are addressed, and future perspectives of miniaturizing SPRi immunosensors with nanotechnologies are discussed.
References
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Journal ArticleDOI

Antimicrobial peptides of multicellular organisms

TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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FactoMineR: An R Package for Multivariate Analysis

TL;DR: FactoMineR an R package dedicated to multivariate data analysis with the possibility to take into account different types of variables (quantitative or categorical), different kinds of structure on the data, and finally supplementary information (supplementary individuals and variables).
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Mechanisms of Antimicrobial Peptide Action and Resistance

TL;DR: The intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance.
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Designing antimicrobial peptides: form follows function

TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
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The expanding scope of antimicrobial peptide structures and their modes of action.

TL;DR: Several intact proteins or protein fragments are now being shown to have inherent antimicrobial activity, suggesting a better understanding of the structure-activity relationships of AMPs is required to facilitate the rational design of novel antimicrobial agents.
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