Journal ArticleDOI
The expanding scope of antimicrobial peptide structures and their modes of action.
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TLDR
Several intact proteins or protein fragments are now being shown to have inherent antimicrobial activity, suggesting a better understanding of the structure-activity relationships of AMPs is required to facilitate the rational design of novel antimicrobial agents.About:
This article is published in Trends in Biotechnology.The article was published on 2011-09-01. It has received 1249 citations till now. The article focuses on the topics: Antimicrobial peptides & Antimicrobial.read more
Citations
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Antibiotic resistance: a rundown of a global crisis.
Bilal Aslam,Wei Wang,Muhammad Imran Arshad,Mohsin Khurshid,Saima Muzammil,Muhammad Hidayat Rasool,Muhammad Atif Nisar,Ruman Farooq Alvi,Muhammad Aamir Aslam,Muhammad Usman Qamar,Muhammad Khalid Farooq Salamat,Zulqarnain Baloch +11 more
TL;DR: Progressive alternate approaches including probiotics, antibodies, and vaccines have shown promising results in trials that suggest the role of these alternatives as preventive or adjunct therapies in future.
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Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Lovisa Ringstad,Camilla Björn,Camilla Björn +5 more
TL;DR: An overview of the biological role, classification, and mode of action of AMPs is provided, the opportunities and challenges to develop these peptides for clinical applications are discussed, and the innovative formulation strategies for application are reviewed.
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Antibacterial surfaces: the quest for a new generation of biomaterials.
TL;DR: Several recent efforts to design a new generation of antibacterial surfaces, which are based on mimicking the surface nanotopography of natural surfaces, are considered.
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The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
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Antimicrobial peptides for therapeutic applications: a review.
TL;DR: This review focuses on small peptides, especially those with less than twelve amino acids, and provides an overview of the relationships between their three-dimensional structures and antimicrobial activities.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
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Cathelicidins, multifunctional peptides of the innate immunity
TL;DR: Multiple actions provide evidence for active participation of cathelicidin peptides in the regulation of the antimicrobial host defenses.
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The co-evolution of host cationic antimicrobial peptides and microbial resistance
Andreas Peschel,Hans-Georg Sahl +1 more
TL;DR: It is proposed that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host–pathogen balance that has shaped the existing CAMP repertoire.