Antioxidative Flavanone Glycosides from the Branches and Leaves of Viscum coloratum
Hui Yao,Zhi-Xin Liao,Qiong Wu,Guang-Qing Lei,Zhi-Jun Liu,Daofeng Chen,Jia-Kuan Chen,Tong-Shui Zhou +7 more
Reads0
Chats0
TLDR
Two new flavanone glucosides were isolated from the branches and leaves of Viscum coloratum NAKAI (Loranthaceae) and showed potent albeit varied degrees of antioxidative activities and the structure-activity relationship is discussed.Abstract:
Two new flavanone glucosides, (2S)-homoeriodictyol 7,4′-di-O-β-D-glucopyranoside (4) and (2R)-eriodictyol 7,4′-di-O-β-D-glucopyranoside (5) were isolated from the branches and leaves of Viscum coloratum (KOMAR) NAKAI (Loranthaceae), along with three known flavanone glucosides: (2S)-homoeriodictyol 7-O-β-D-glucopyranoside (1), (2S)-eriodictyol 7-O-β-D-glucopyranoside (2), and (2S)-naringenin 7-O-β-D-glucopyranoside (3). The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. All the compounds showed potent albeit varied degrees of antioxidative activities and the structure–activity relationship is discussed.read more
Citations
More filters
Journal ArticleDOI
Flavonoids and their glycosides, including anthocyanins
Nigel C. Veitch,Renée J. Grayer +1 more
TL;DR: This review describes more than 600 new examples of naturally occurring flavonoids found either as aglycones or glycosides, comprising flavones, flavonols, chalcones, dihydrochalcones and anthocyanidins.
Journal ArticleDOI
The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes.
TL;DR: Findings suggest that eriodictyol can be used to protect keratinocytes from UV-induced damage, implying the presence of a complex structure-activity relationship (SAR) in the differential apoptosis-modulating activities of various flavonoids.
Journal ArticleDOI
Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells.
Hyuk Yoon,Tae Woo Kim,Soon Young Shin,Mi Joo Park,Yeonjoong Yong,Dong Woon Kim,Tasneem Islam,Young Han Lee,Kang-Yeoun Jung,Yoongho Lim +9 more
TL;DR: This result demonstrates the rationale for the different inhibitory activities of the naringenin derivatives and could be used for designing cancer therapeutic or preventive flavanone-derived agents.
Journal ArticleDOI
The tumor-growth inhibitory activity of flavanone and 2′-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs
Yung-Chin Hsiao,Yih-Shou Hsieh,Wu-Hsien Kuo,Hui-Ling Chiou,Shun-Fa Yang,Shun-Fa Yang,Whei-Ling Chiang,Shu-Chen Chu +7 more
TL;DR: Flavanone and 2'-OH flavanone were evidenced by its inhibition on the growth of A549 and Lewis lung carcinoma cells in vivo as well as with anti-cancer drug, doxorubicin.
Journal ArticleDOI
Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity
TL;DR: The presence of eriodictyol-7-O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.
References
More filters
Journal ArticleDOI
Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels☆
TL;DR: The staining procedure for localizing superoxide dismutase on polyacrylamide electrophoretograms has been applied to extracts obtained from a variety of sources and could thus be assayed either in crude extracts or in purified protein fractions.
Journal ArticleDOI
Structure−Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers
Paul Cos,Li Ying,M. Calomme,Jia P. Hu,K. Cimanga,Bart Van Poel,Luc Pieters,A. Vlietinck,Dirk Vanden Berghe +8 more
TL;DR: The structure-activity relationship of flavonoids as inhibitors of xanthine oxidase and as scavengers of the superoxide radical, produced by the action of the enzyme xanthines oxidase, was investigated and showed slightly higher inhibitory activity than flavonols.
Journal ArticleDOI
Circular dichroism, optical rotatory dispersion and absolute configuration of flavanones, 3-hydroxyflavanones and their glycosides : Determination of aglycone chirality in flavanone glycosides☆
TL;DR: In this paper, the 2 S configuration and 3-hydroxy-flavanones of 2 R, 3 R configuration, having equatorial 2-aryl substituents in the former or diequatorial 2,3-substituents of the latter, exhibit a positive Cotton effect due to the n → π * transition (∼ 330 nm) and a negative Cotton effect in the n α π ∆ * region(∼ 280-290 nm).
Journal ArticleDOI
Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch).
TL;DR: In this article, nine phenolic compounds were isolated from the ethyl acetate and n-butanol fractions of almond (Prunus amygdalus) skins, based on NMR data, MS data, and comparison with the literature.
Journal ArticleDOI
Antioxidant chalcone glycosides and flavanones from Maclura (Chlorophora) tinctoria.
TL;DR: Four chalcone glycosides, including three new natural products, and three flavanones were isolated from the methanol extract of stem bark of Maclura tinctoria and the results showed that compound 3 was the most active in both antioxidant assays.