Antipsychotic-Induced Weight Gain and Clinical Improvement: A Psychiatric Paradox
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This article is published in Frontiers in Psychiatry.The article was published on 2020-11-03 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Clozapine & Olanzapine.read more
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Journal ArticleDOI
Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review.
Miquel Bioque,Alexandre González-Rodríguez,Clemente Garcia-Rizo,Jesús Cobo,José Antonio Monreal,Judith Usall,Virginia Soria,Javier Labad +7 more
TL;DR: Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.
Journal ArticleDOI
The usefulness of Olanzapine plasma concentrations in monitoring treatment efficacy and metabolic disturbances in first-episode psychosis.
Joan Albert Arnaiz,C Rodrigues-Silva,G. Mezquida,Silvia Amoretti,M.J. Cuesta,D. Fraguas,Antonio Lobo,Ana González-Pinto,M C Díaz-Caneja,Iluminada Corripio,Eduard Vieta,Immaculada Baeza,Anna Mané,Clemente Garcia-Rizo,Miquel Bioque,Jerónimo Saiz,M. Bernardo,Sergi Mas +17 more
TL;DR: The results suggest that therapeutic drug monitoring of Olanzapine could be helpful to evaluate therapeutic efficacy and metabolic dysfunction in FEP patients treated with OlanzAPine.
Journal ArticleDOI
Do Leptin Play a Role in Metabolism-Related Psychopathological Symptoms?
Yelei Zhang,Xiaoyue Li,Xianhu Yao,Yating Yang,Xiaoshuai Ning,Tongtong Zhao,Lei Xia,Yulong Zhang,Kai Zhang,Huanzhong Liu +9 more
TL;DR: In this paper, the authors investigated the relationship between serum leptin levels, body mass index (BMI), and psychopathology symptoms in patients with schizophrenia and found that the increase in leptin levels is responsible for antipsychotic-induced weight gain and improved psychopathological symptoms.
Journal ArticleDOI
The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets
María Carmen Iglesias-Osma,María José García-Barrado,David Hernández González,Kévin Perrier,Pénélope Viana,Christian Carpéné +5 more
Journal ArticleDOI
Association between antipsychotic medication and clinically relevant weight change: meta-analysis
TL;DR: In this article , the proportion of patients with clinically relevant weight gain (CRWG), defined as ≥7% weight gain and ≥7 % weight loss, was assessed. But the impact of diagnosis on CRWG remains inconclusive.
References
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Journal ArticleDOI
Narrative review: the management of acute decompensated heart failure.
Paul E. Marik,Mark Flemmer +1 more
TL;DR: Evidence-based recommendations are provided for the diagnosis and management of acute decompensated heart failure including morphine, high-dose diuretics, and inotropic agents may be harmful.
Journal ArticleDOI
A Controlled Study
TL;DR: I feel let down by the overstatement and it does not seem cricket to whet the reader's appetite by including in the title the come-on phrase "controlled study" when the method used is not really rigidly controlled.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.
Toby Pillinger,Toby Pillinger,Robert A. McCutcheon,Robert A. McCutcheon,Luke Vano,Luke Vano,Yuya Mizuno,Yuya Mizuno,Yuya Mizuno,Atheeshaan Arumuham,Atheeshaan Arumuham,Guy Frederick Lanyon Hindley,Guy Frederick Lanyon Hindley,Katherine Beck,Katherine Beck,Sridhar Natesan,Sridhar Natesan,Orestis Efthimiou,Andrea Cipriani,Andrea Cipriani,Oliver D. Howes,Oliver D. Howes +21 more
TL;DR: Marked differences exist between antipsychotics in terms of metabolic side-effects, with olanzapine and clozapine exhibiting the worst profiles and aripiprazole, brexpiprazoles, cariprazine, lurasidone, and ziprasidone the most benign profiles.