Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function
Gavril Hercz,York Pei,Celia M. T. Greenwood,Arif Manuel,Carl Saiphoo,William G. Goodman,Gino V. Segre,Stanley S. A. Fenton,Sherrard Dj +8 more
TLDR
The aplastic lesion is the most common form of renal osteodystrophy, with aluminum intoxication implicated in only 1/3 of the cases, and additional risk factors included treatment with peritoneal dialysis, ingestion of calcium carbonate, diabetes mellitus and advanced age.About:
This article is published in Kidney International.The article was published on 1993-10-01 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Osteodystrophy & Renal osteodystrophy.read more
Citations
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Journal ArticleDOI
Bone metabolism and disease in chronic kidney disease
Journal ArticleDOI
Severely reduced production of klotho in human chronic renal failure kidney.
Noritoshi Koh,Toshihiko Fujimori,Shuhei Nishiguchi,Akihiro Tamori,Susumu Shiomi,Tatsuya Nakatani,Kazunobu Sugimura,Taketoshi Kishimoto,Satoko Kinoshita,Tetsuo Kuroki,Yo-ichi Nabeshima +10 more
TL;DR: The results suggest that the decrease in kl gene expression in CRF patients may underlie the deteriorating process of multiple complications in theCRF patients.
Journal ArticleDOI
Hyperphosphatemia of chronic kidney disease
TL;DR: The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented.
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Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function.
Ping Gao,Stephen Scheibel,Pierre D’Amour,Markus R. John,Sudhaker D Rao,Heinrich Schmidt-Gayk,Thomas L. Cantor +6 more
TL;DR: It is identified that the previously described non‐(1–84)PTH fragments are aminoterminally truncated with similar hydrophobicity as PTH(7–84), and these PTH fragments will be present not only in patients with secondary hyperparathyroidism (2°‐HPT) of uremia, but also in Patients with primary hyper parathyroidistan (1°‐hPT) and normal persons.
References
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Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
Samuel R. Nussbaum,R. J. Zahradnik,J. R. Lavigne,G. L. Brennan,K. Nozawa-Ung,L. Y. Kim,Henry T. Keutmann,C.C. Wang,John T. Potts,Gino V. Segre +9 more
TL;DR: The sensitivity, specificity, and rapid turnaround time of this two-site IRMA should advance the laboratory evaluation of patients with disorders of calcium metabolism.
Journal ArticleDOI
The spectrum of bone disease in end-stage renal failure—An evolving disorder
Donald J. Sherrard,Gavril Hercz,York Pei,Norma A. Maloney,Celia M. T. Greenwood,Arif Manuel,Carl Saiphoo,Stanley S. A. Fenton,Gino V. Segre +8 more
TL;DR: It is suggested that peritoneal dialysis, perhaps by maintaining calcium at higher levels, may more effectively suppress the parathyroid gland.
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Calcium Carbonate as a Phosphate Binder in Patients with Chronic Renal Failure Undergoing Dialysis
Eduardo Slatopolsky,Carol Weerts,S. Lopez-Hilker,Kathryn Norwood,Mary Zink,David W. Windus,James A. Delmez +6 more
TL;DR: Calcium carbonate successfully lowered serum phosphorus levels and raised serum calcium levels in the majority of the authors' patients, thereby confirming that this agent may be a satisfactory substitute for traditional phosphate binders that contain aluminum.
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The Prevalence of Bone Aluminum Deposition in Renal Osteodystrophy and Its Relation to the Response to Calcitriol Therapy
TL;DR: It is concluded that aluminum deposition is associated with impaired bone formation or mineralization and with a poor response to calcitriol therapy and with an increased likelihood of recurrence in renal osteodystrophy.
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Intact Parathyroid Hormone Overestimates the Presence and Severity of Parathyroid-Mediated Osseous Abnormalities in Uremia*
TL;DR: It is demonstrated that elevated PTH concentrations are necessary to maintain normal bone remodeling in the uremic setting and that it may not be necessary to attain normal serum intact PTH levels to control the osseous manifestations of PTH excess in Uremic subjects.