The spectrum of bone disease in end-stage renal failure—An evolving disorder
Donald J. Sherrard,Gavril Hercz,York Pei,Norma A. Maloney,Celia M. T. Greenwood,Arif Manuel,Carl Saiphoo,Stanley S. A. Fenton,Gino V. Segre +8 more
TLDR
It is suggested that peritoneal dialysis, perhaps by maintaining calcium at higher levels, may more effectively suppress the parathyroid gland.About:
This article is published in Kidney International.The article was published on 1993-02-01 and is currently open access. It has received 686 citations till now. The article focuses on the topics: Bone disease & Renal osteodystrophy.read more
Citations
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KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
Journal ArticleDOI
Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
Sharon M. Moe,Tilman B. Drüeke,John Cunningham,Wayne K. Goodman,Kevin J. Martin,Klaus Olgaard,Susan M. Ott,Stuart M. Sprague,Norbert Lameire,Garabed Eknoyan +9 more
TL;DR: It is recommended that the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD, and the term CKD-Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD.
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Bone metabolism and disease in chronic kidney disease
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Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone
Maria Coco,Heather Rush +1 more
TL;DR: Despite more aggressive therapy directed toward bone health in dialysis patients in recent years, the incidence of hip fractures and their devastating morbidity and mortality remained unchanged over the past decade, and lower PTH levels may predispose to earlier mortality.
References
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Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
A. Michael Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,Pierre J. Meunier,Susan M. Ott,Robert R. Recker +7 more
TL;DR: A committee of the Society to develop a unified system of termnology, suitable for adoption by the Journal of Bone and Mineral Research as part of its Instructions to Authors is formed, and is as complex and conceptually difficult as the field with which it deals.
Journal Article
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
A. M. Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,P. J. Meunier,Susan M. Ott,Robert R. Recker +7 more
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Extension of multiple range tests to group means with unequal numbers of replications
Abstract: In many fields of research, one is faced with the task of comparing the effects of treatments which have been replicated unequally. This happens for a number of reasons. In an experiment on animals, some may get sick and have to be removed from the experiment. In some experiments, the amount of material available for certain treatments may not be as much as for other treatments. If the experimenter has specified orthogonal contrasts that he is interested in before he runs the experiment, one can test the various treatment effects by an F-test after the treatment sum of squares has been partitioned into individual degrees of freedom for each orthogonal contrast. If the experimenter has not specified orthogonal contrasts, one is faced with the problem of deciding which treatments are significantly different. Several writers, including Duncan, Keuls, Newman, and Tukey, have developed multiple range tests to show differences among treatments that have been replicated the same number of times and when nothing was specified concerning the treatments. Duncan [1] compares the above methods and gives citations. This extension to unequal numbers of replications will be exemplified with reference to Duncan's "New Multiple Range Test," but is applicable to any of the above writers' tests; all one has to do is use their tabled ranges. In Duncan's test for an equal number of replications, the difference between any two ranked means is significant if the difference exceeds a shortest significant range. This shortest significant range is designated by R, and is obtained by multiplying the standard error of a mean, s,, by a given value, zn2, obtained from a table of significant studentized ranges which Duncan has tabled for both the 5% and 1% test. In Duncan's terminology, n2 is the degrees of freedom of the error mean square and p = 1, 2, * *, t is the number of means concerned. Consider an experiment with five treatments, A, B. C, D, and E, each replicated n times. Suppose on ranking the means from low to high one obtains
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Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
Samuel R. Nussbaum,R. J. Zahradnik,J. R. Lavigne,G. L. Brennan,K. Nozawa-Ung,L. Y. Kim,Henry T. Keutmann,C.C. Wang,John T. Potts,Gino V. Segre +9 more
TL;DR: The sensitivity, specificity, and rapid turnaround time of this two-site IRMA should advance the laboratory evaluation of patients with disorders of calcium metabolism.
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Renal bone disease 1990: an unmet challenge for the nephrologist.
TL;DR: A rational approach to the treatment of renal bone disease requires a basic understanding of the anatomic physiology of bone, the pathophysiologic effects of renal failure on mineral metabolism and bone, and the various available therapeutic modalities.