Book ChapterDOI
Application of Microbial Toxins for Cancer Therapy
Rama Shanker Verma,Sirisha Potala,Mrudula Mathew,Swati Choudhary +3 more
- pp 647-662
TLDR
Continuous efforts are being made to improve the specificity and efficacy of immunotoxins, to reduce size effects of the drugs, reduce immunogenicity and to improve better pharmacokinetics for drugs delivery.Abstract:
The principle of selective targeting of immunotoxins lies on the basis that cancer cells usually have few or specific growth factors/receptors/antigens highly over expressed on their surface. Ligands corresponding to these molecules are conjugated to modified toxins (modified to loss its native function) isolated form variety of bacterial populations. Normal cells either do not express these molecules or express at relatively low number leading to no or minimal adverse effects. The basic mechanism of action of these immunotoxins depends on the toxins employed. In this regard continuous efforts are being made to (i) Identity molecules exclusively expressed in cancer cells, (ii) to improve the specificity and efficacy (iii) reduce size effects of the drugs, (iv) Reduce immunogenicity and (v) to improve better pharmacokinetics for drugs delivery.read more
Citations
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Journal ArticleDOI
In Silico Analyses of Staphylococcal Enterotoxin B as a DNA Vaccine for Cancer Therapy
TL;DR: Assessment of the immunoreactivity of a SEB-coding DNA construct that serves as a DNA vaccine for breast cancer therapy revealed that apparently the construct could be efficiently expressed in mouse model, and could act as an amenable adjuvant in cancer immunotherapy.
References
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Journal ArticleDOI
Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity.
Tie Fu Liu,Jeffrey O Urieto,Joseph E. Moore,Mark Steven Miller,A. Corinne Lowe,Andrew Thorburn,Arthur E. Frankel +6 more
TL;DR: A diphtheria toxin fusion protein composed of the catalytic and translocation domains of DT fused to interleukin-3 fused to IL-3 showed cytotoxicity to leukemic blasts in vitro and in vivo and minimal damage to normal tissues in nonhuman primate models.
Journal ArticleDOI
Molecular Characterization of Diphtheria Toxin Repressor (dtxR) Genes Present in Nontoxigenic Corynebacterium diphtheriae Strains Isolated in the United Kingdom
TL;DR: It is demonstrated that, if lysogenised by a bacteriophage, nontoxigenic strains circulating in the United Kingdom could produce toxin and therefore represent a potential reservoir for toxigenic C. diphtheriae.
Journal ArticleDOI
Retinoid regulation of interleukin-2 receptors on human T-cells
TL;DR: The ability of RA to upregulate IL-2R expression and enhance the activation state of Hut78 cells is demonstrated and the physiologic relevance of the Hut78 cell line model is suggested.
Journal ArticleDOI
The evolving TNM cancer staging system: an essential component of cancer care
TL;DR: Cancer staging is an important component, not only of patient care, but also of cancer research and control.
Journal ArticleDOI
The effects of helix breaking mutations in the diphtheria toxin transmembrane domain helix layers of the fusion toxin dab389il-2
TL;DR: It is proposed that each of the three helical layers of the transmembrane domain plays a critical role in the productive delivery of the catalytic domain to the cell cytosol.