Journal ArticleDOI
Application of ω-Transaminases in the Pharmaceutical Industry
Stephen Kelly,Stefan Pohle,Scott Wharry,Stefan Mix,Christopher C. R. Allen,Thomas S. Moody,Brendan Gilmore +6 more
TLDR
This review explores the application of ω-TAms for pharmaceutical production, providing a comprehensive overview of their uses, beginning with initial applications through to the present day.Abstract:
Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential “green alternative” to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.read more
Citations
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Journal ArticleDOI
Biocatalysis: Enzymatic Synthesis for Industrial Applications
TL;DR: A review of biocatalysis with a special focus on scalable chemical production using enzymes discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes.
Journal ArticleDOI
Engineering new catalytic activities in enzymes
Kai Chen,Frances H. Arnold +1 more
TL;DR: This Review outlines the ways that enzymes have been engineered to achieve reactivities well beyond their original functions and identifies genetically encoded catalysts that can be tuned and diversified by engineering the protein sequence.
Journal ArticleDOI
New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines.
TL;DR: This review aims to provide a concise overview of modern transition-metal catalyzed approaches to alkylamine synthesis and their functionalization.
Journal ArticleDOI
Broadening the Scope of Biocatalysis in Sustainable Organic Synthesis
TL;DR: This Review is aimed at synthetic organic chemists who may be familiar with organometallic catalysis but have no experience with biocatalysis, and seeks to provide an answer to the perennial question: if it is so attractive, why wasn't it extensively used in the past?
Journal ArticleDOI
Photo-Biocatalysis: Biotransformations in the Presence of Light
Luca Schmermund,Valentina Jurkaš,Fatma Feyza Özgen,Giovanni Davide Barone,Hanna C. Büchsenschütz,Christoph K. Winkler,Sandy Schmidt,Robert Kourist,Wolfgang Kroutil +8 more
TL;DR: An overview of the various approaches for using light in biocatalysis is given and enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction.
References
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Engineering the third wave of biocatalysis
Uwe T. Bornscheuer,Gjalt W. Huisman,Romas J. Kazlauskas,Romas J. Kazlauskas,Stefan Lutz,Jeffrey C. Moore,Karen Robins +6 more
TL;DR: Applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step are discussed.
Journal ArticleDOI
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Christopher Savile,Jacob M. Janey,Emily Mundorff,Jeffrey C. Moore,Sarena Tam,William R. Jarvis,Jeffrey Colbeck,Anke Krebber,Fred J. Fleitz,Jos Brands,Paul N. Devine,Gjalt W. Huisman,Gregory Hughes +12 more
TL;DR: An efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic compound sitagliptin is reported, underscoring the maturation of bioc atalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals.
Journal ArticleDOI
Industrial Methods for the Production of Optically Active Intermediates
Michael Breuer,Klaus Ditrich,Tilo Habicher,Bernhard Hauer,Maria Kesseler,Rainer Stürmer,Thomas Zelinski +6 more
TL;DR: For the industrial implementation of many transformations alternative methods are available and the advantages of the individual methods will be discussed herein and exemplified by syntheses of relevant compounds.
Journal ArticleDOI
Key green chemistry research areas—a perspective from pharmaceutical manufacturers
David J. C. Constable,Peter J. Dunn,John D. Hayler,Guy R. Humphrey,Johnnie L. Leazer,Russell J. Linderman,Kurt T. Lorenz,Julie B. Manley,Bruce A. Pearlman,Andrew S. Wells,Aleksey Zaks,Tony Y. Zhang +11 more
TL;DR: An assessment of the current state of the art in green chemistry and green engineering areas and to highlight areas for future improvement are provided.
Journal ArticleDOI
Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.
Andrew C. Eliot,Jack F. Kirsch +1 more
TL;DR: The combination of new sequences and structures enables better reconstruction of their evolutionary heritage and illuminates unrecognized similarities within this diverse group of enzymes.