Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.
TLDR
Findings for the relationship of S. cerevisiae to prokaryotic as well as to higher eukaryotic organisms and for general regulatory mechanisms occurring in a living cell such as initiation of transcription, enzyme regulation, and the regulation of a metabolic branch point are discussed.About:
This article is published in Microbiological Research.The article was published on 1991-09-01 and is currently open access. It has received 246 citations till now. The article focuses on the topics: Aromatic amino acids & Amino acid.read more
Citations
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Journal ArticleDOI
Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast
Krishnamurthy Natarajan,Michael R. Meyer,Belinda M. Jackson,David J. Slade,Christopher J. Roberts,Alan G. Hinnebusch,Matthew J. Marton +6 more
TL;DR: The broad transcriptional response evoked by Gcn4p is produced by diverse stress conditions, and numerous genes encoding protein kinases and transcription factors were identified as targets, suggesting that Gcn 4p is a master regulator of gene expression.
Journal ArticleDOI
The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds.
TL;DR: This review gives a short overview of the shikimate pathway and briefly introduces the seven enzymes that catalyze the sequential steps of the pathway, and discusses some regulatory features of severa1 of the enzymes.
Journal ArticleDOI
Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.
Özgür Bayram,Gerhard H. Braus +1 more
TL;DR: A comprehensive picture of the molecular interplay between the velvet domain protein family, LaeA and other nuclear regulatory proteins in response to various signal transduction pathway starts to emerge from a jigsaw puzzle of several recent studies.
Journal ArticleDOI
Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress
TL;DR: All cells undergo rapid transcriptional reprogramming in response to environmental changes by mobilizing transcriptional activators and repressors.
Journal ArticleDOI
Metabolic engineering of muconic acid production in Saccharomyces cerevisiae.
TL;DR: This work collectively demonstrates that yeast has the potential to be a platform for the bioproduction of muconic acid and suggests an area that is ripe for future metabolic engineering efforts.
References
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Book ChapterDOI
Prediction of the secondary structure of proteins from their amino acid sequence.
Peter Y. Chou,Gerald D. Fasman +1 more
Journal ArticleDOI
Transformation of yeast
TL;DR: This work has used recently developed hybridization and restriction endonuclease mapping techniques to demonstrate directly the presence of the transforming DNA in the yeast genome and also to determine the arrangement of the sequences that were introduced.
Journal ArticleDOI
Codon selection in yeast.
TL;DR: Extreme codon bias is seen for the Saccharomyces cerevisiae genes for the fermentative alcohol dehydrogenase isozyme I (ADH-I) and glyceraldehyde-3-phosphate dehydrogenased genes and a similar phenomenon is observed in the codon preferences of highly expressed genes in Escherichia coli.
Journal ArticleDOI
The “initiator” as a transcription control element
Stephen T. Smale,David Baltimore +1 more
TL;DR: The Inr constitutes the simplest functional promoter that has been identified and provides one explanation for how promoters that lack TATA elements direct transcription initiation.
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High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules
TL;DR: A set of vector DNAs (Y vectors) useful for the cloning of DNA fragments in Saccharomyces cerevisiae (yeast) and in Escherichia coli are characterized in this paper.