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Artificial intelligence and guidance of medicine in the bubble.

TLDR
In this paper, the advanced bubble-based drug-delivery system, integrated with artificial intelligence for guidance, holds great promise for the targeted delivery of drugs and medicines, which can effectively circulate through the whole body safely and efficiently to reach the target area.
Abstract
Microbubbles are nanosized gas-filled bubbles. They are used in clinical diagnostics, in medical imaging, as contrast agents in ultrasound imaging, and as transporters for targeted drug delivery. They can also be used to treat thrombosis, neoplastic diseases, open arteries and vascular plaques and for localized transport of chemotherapies in cancer patients. Microbubbles can be filled with any type of therapeutics, cure agents, growth factors, extracellular vesicles, exosomes, miRNAs, and drugs. Microbubbles protect their cargo from immune attack because of their specialized encapsulated shell composed of lipid and protein. Filled with curative medicine, they could effectively circulate through the whole body safely and efficiently to reach the target area. The advanced bubble-based drug-delivery system, integrated with artificial intelligence for guidance, holds great promise for the targeted delivery of drugs and medicines.

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Journal ArticleDOI

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

TL;DR: The sources of extracellular vesicles, including plant, salivary and urinary sources which are easily available but less sought after compared with blood and tissue are discussed.
Journal ArticleDOI

Diagnostic and Therapeutic Potential of Extracellular Vesicles.

TL;DR: Extracellular vesicles (EVs) are naturally phospholipid enclosed nanoveicles released by many cells in the body as discussed by the authors, which are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules.
Journal ArticleDOI

Different Sourced Extracellular Vesicles and Their Potential Applications in Clinical Treatments

Leila Bahmani, +1 more
- 21 Jun 2022 - 
TL;DR: This review describes in detail different EVs derived from distinct cell sources, compare their advantages and disadvantages, and recapitulate their therapeutic effects on various human disorders to highlight the progress made in harnessing EVs for clinical applications.
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Exosome engineering for efficient and targeted drug delivery: Current status and future perspective

TL;DR: Exosomes are membrane-bound vesicles that are released by most cells and carry nucleic acids, cytokines, growth factors, proteins, lipids, and metabolites as discussed by the authors .
Journal ArticleDOI

The barrier and interface mechanisms of the brain barrier, and brain drug delivery

TL;DR: In this paper , the authors summarized the classification of the brain barrier, the composition and role of the basic structures of the BBB, and the transport, barrier, and destruction mechanisms.
References
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Journal ArticleDOI

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.

TL;DR: An up to date snapshot of nanomedicines either currently approved by the US FDA, or in the FDA clinical trials process is provided, and there is a trend towards the development of more complex materials comprising micelles, protein-based NPs, and also the emergence of a variety of inorganic and metallic particles in clinical trials.
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A rapid and robust method for single cell chromatin accessibility profiling

TL;DR: A simple and robust plate-based single-cell ATAC-seq method that works in fresh and cryopreserved cells and identifies distinct immune cell types and reveal cell type-specific regulatory regions and related transcription factors is developed.
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Blood-brain barrier delivery.

TL;DR: Brain drug development programs of the future need to be re-configured so that drugs are formulated to enable transport into the brain via endogenous BBB transporters.
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A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

TL;DR: This review of molecular imaging of intact living subjects focuses specifically on small molecules, peptides, aptamers, engineered proteins, and nanoparticles and cites examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics.
Journal ArticleDOI

Strong two-photon-induced fluorescence from photostable, biocompatible nitrogen-doped graphene quantum dots for cellular and deep-tissue imaging.

TL;DR: The biocompatible nitrogen-doped graphene quantum dots (N-GQDs) are reported as efficient two-photon fluorescent probes for cellular and deep-tissue imaging and can achieve a large imaging depth of 1800 μm, significantly extending the fundamental two- photon imaging depth limit.
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