Open AccessJournal Article
Aspects on receptor regulation and isoreceptor identification.
TLDR
Criteria for isoreceptor identification are introduced on a quantitative basis, that is by means of comparisons of ED50 values obtained, using a certain agonist, for the different responses triggered by the binding of the ligand with the respective class of receptors.Abstract:
The present paper introduces a classification of receptor regulation. This classification takes into consideration especially the type of regulation (homoregulation vs. heteroregulation) and the biochemical mechanisms subserving the regulation process. Furthermore, criteria for isoreceptor identification are introduced on a quantitative basis, that is by means of comparisons of ED50 values obtained, using a certain agonist, for the different responses triggered by the binding of the ligand with the respective class of receptors. Finally, a possible case of isoreceptor interconversion is extensively discussed and a model for such an interconversion is suggested.read more
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Adenosine–Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders
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Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia
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Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function
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Book ChapterDOI
Coexistence of neuronal messengers--an overview.
Tomas Hökfelt,V Holets,W.A. Staines,Björn Meister,T. Melander,Martin Schalling,Marianne Schultzberg,Freedman J,Håkan Björklund,Lars Olson +9 more
TL;DR: Results demonstrating that neurons often contain more than one chemical compound demonstrate that multiple messengers may provide the means for increasing the capacity for information transfer in the nervous system.