Journal ArticleDOI
Assembly of infectious hepatitis C virus particles
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TLDR
This review focuses on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle and its tight link with host cell lipid synthesis.About:
This article is published in Trends in Microbiology.The article was published on 2011-02-01. It has received 426 citations till now. The article focuses on the topics: Lipid droplet.read more
Citations
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Journal ArticleDOI
Interferon-Stimulated Genes: A Complex Web of Host Defenses
TL;DR: This review begins by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production and describes ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the Jak-STAT pathway.
Journal ArticleDOI
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
TL;DR: Ongoing and future trials will determine the best antiviral combinations and whether the current seemingly rich pipeline is sufficient for successful treatment of all patients in the face of major challenges, such as HCV diversity, viral resistance, the influence of host genetics, advanced liver disease and other co-morbidities.
Journal ArticleDOI
Living in the liver: hepatic infections
TL;DR: The interplay between pathogens and host factors that promote pathogen elimination and maintain organ integrity or that allow pathogen persistence are described.
Journal ArticleDOI
Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication
Inés Romero-Brey,Andreas Merz,Abhilash I. Chiramel,Ji-Young Lee,Petr Chlanda,Uta Haselman,Rachel Santarella-Mellwig,Anja Habermann,Simone Hoppe,Stephanie Kallis,Paul Walther,Claude Antony,Jacomine Krijnse-Locker,Ralf Bartenschlager +13 more
TL;DR: The morphology of the membranous rearrangements induced in HCV-infected cells resemble those of the unrelated picorna-, corona- and arteriviruses, but are clearly distinct from those from the closely related flavivirus.
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Arbidol as a broad-spectrum antiviral: an update.
TL;DR: This review will explore the possibility and pertinence of ARB as a broad-spectrum antiviral, after a careful examination of its physico-chemical properties, pharmacokinetics, toxicity, and molecular mechanisms of action.
References
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Journal ArticleDOI
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line
TL;DR: This work defines the structure of HCV replicons functional in cell culture and provides the basis for a long-sought cellular system that should allow detailed molecular studies ofHCV and the development of antiviral drugs.
Journal ArticleDOI
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
Takaji Wakita,Thomas Pietschmann,Takanobu Kato,Takanobu Kato,Tomoko Date,Michiko Miyamoto,Zijiang Zhao,Krishna K. Murthy,Anja Habermann,Hans-Georg Kräusslich,Masashi Mizokami,Ralf Bartenschlager,T. Jake Liang +12 more
TL;DR: It is shown that the JFH1 genome replicates efficiently and supports secretion of viral particles after transfection into a human hepatoma cell line (Huh7) and provides a powerful tool for studying the viral life cycle and developing antiviral strategies.
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Etienne Meylan,Joseph Curran,Kay Hofmann,Darius Moradpour,Marco Binder,Ralf Bartenschlager,Jürg Tschopp +6 more
TL;DR: Cardif is described, a new CARD-containing adaptor protein that interacts with RIG-I and recruits IKKα, IKKβ and IKKɛ kinases by means of its C-terminal region, leading to the activation of NF-κB and IRF3.
Journal ArticleDOI
Replication of hepatitis C virus
TL;DR: The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps.
Journal ArticleDOI
The lipid droplet is an important organelle for hepatitis C virus production.
Yusuke Miyanari,Kimie Atsuzawa,Nobuteru Usuda,Koichi Watashi,Takayuki Hishiki,Margarita Zayas,Ralf Bartenschlager,Takaji Wakita,Makoto Hijikata,Kunitada Shimotohno +9 more
TL;DR: A novel function of LDs is revealed in the assembly of infectious HCV and a new perspective on how viruses usurp cellular functions is provided.
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