Association between Alcohol Consumption and Cancers in the Chinese Population—A Systematic Review and Meta-Analysis
Ying Li,Huan Yang,Jia Cao +2 more
TLDR
Combined results of case-control and cohort studies showed that alcohol consumption was associated with 1.78- and 1.40-fold higher risks of EC and gastric cancer but was not significantly associated with lung cancer.Abstract:
Background
Alcohol consumption is increasing worldwide and is associated with numerous cancers. This systematic review examined the role of alcohol in the incidence of cancer in the Chinese population.
Methods
Medline/PubMed, EMBASE, CNKI and VIP were searched to identify relevant studies. Cohort and case-control studies on the effect of alcohol use on cancers in Chinese were included. Study quality was evaluated using the Newcastle-Ottawa Scale. Data were independently abstracted by two reviewers. Odds ratios (OR) or relative risks (RR) were pooled using RevMan 5.0. Heterogeneity was evaluated using the Q test and I-squared statistic. P<.01 was considered statistically significant.
Results
Pooled results from cohort studies indicated that alcohol consumption was not associated with gastric cancer, esophageal cancers (EC) or lung cancer. Meta-analysis of case-control studies showed that alcohol consumption was a significant risk factor for five cancers; the pooled ORs were 1.79 (99% CI, 1.47–2.17) EC, 1.40 (99% CI, 1.19–1.64) gastric cancer, 1.56 (99% CI, 1.16–2.09) hepatocellular carcinoma, 1.21 (99% CI, 1.00–1.46) nasopharyngeal cancer and 1.71 (99% CI, 1.20–2.44) oral cancer. Pooled ORs of the case-control studies showed that alcohol consumption was protective for female breast cancer and gallbladder cancer: OR 0.76 (99% CI, 0.60–0.97) and 0.70 (99% CI, 0.49–1.00) respectively. There was no significant correlation between alcohol consumption and lung cancer, colorectal cancer, pancreatic cancer, cancer of the ampulla of Vater, prostate cancer or extrahepatic cholangiocarcinoma. Combined results of case-control and cohort studies showed that alcohol consumption was associated with 1.78- and 1.40-fold higher risks of EC and gastric cancer but was not significantly associated with lung cancer.
Conclusions
Health programs focused on limiting alcohol intake may be important for cancer control in China. Further studies are needed to examine the interaction between alcohol consumption and other risk factors for cancers in Chinese and other populations.read more
Citations
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Epidemiology of Esophageal Cancer in Japan and China
Yingsong Lin,Yukari Totsuka,Yutong He,Shogo Kikuchi,You-Lin Qiao,Junko Ueda,Wenqiang Wei,Manami Inoue,Hideo Tanaka +8 more
TL;DR: A well-designed multidisciplinary epidemiologic study is needed to examine the role of diet and eating habits in ESCC risk, including cancer burden, patterns of incidence and mortality, sex ratio of mortality, risk factor profiles, and genetic variants.
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Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)
TL;DR: The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012 and to have cancer surveillance at the national-level to collect and utilise data for cancer prevention and control programs.
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Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
TL;DR: This is the most comprehensive meta-analysis of CCA risk factors to date and the strongest risk factors for both iCCA and eCCA are cysts and stones in the bile ducts, cirrhosis and viruses hepatitis B and C.
Journal ArticleDOI
Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies
Federica Turati,Carlotta Galeone,Matteo Rota,Matteo Rota,Claudio Pelucchi,Eva Negri,Vincenzo Bagnardi,Vincenzo Bagnardi,Giovanni Corrao,Paolo Boffetta,C. La Vecchia,C. La Vecchia +11 more
TL;DR: A moderate detrimental role of consumption of 3 or more alcoholic drinks per day on liver cancer, and a lack of association with moderate drinking is suggested.
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Alcohol Use and Breast Cancer: A Critical Review.
TL;DR: All levels of evidence showed a risk relationship between alcohol consumption and the risk of breast cancer, even at low levels of consumption, and to the amount of alcohol consumed globally, the incidence of and mortality from alcohol-attributable breast cancer is large.
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