Journal ArticleDOI
Association between functional polymorphism in EGF gene and malignant melanoma
Majid Shahbazi,Vera Pravica,Najma Nasreen,Hana Fakhoury,Anthony A. Fryer,Richard C. Strange,Peter E. Hutchinson,J.E. Osborne,John T. Lear,Andrew G. Smith,Ian V. Hutchinson +10 more
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TLDR
It is suggested that high EGF production might be important in the development of malignant melanoma.About:
This article is published in The Lancet.The article was published on 2002-02-02. It has received 252 citations till now. The article focuses on the topics: Allele frequency & Genotype.read more
Citations
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Systems biology of cisplatin resistance: past, present and future
Lorenzo Galluzzi,Ilio Vitale,Judith Michels,Catherine Brenner,Gyorgy Szabadkai,A Harel-Bellan,Maria Castedo,Guido Kroemer +7 more
TL;DR: Recent systems biology studies aimed at deconvoluting the complex circuitries that underpin cisplatin resistance are discussed, and how their findings might drive the development of rational approaches to tackle this clinically relevant problem.
Journal ArticleDOI
Trend tests for case-control studies of genetic markers: power, sample size and robustness.
TL;DR: Simulation results of the robustness of these two tests indicate that the more computationally involved MAX test is preferable, and formulas for the required sample size to achieve a prespecified power that account for the need to estimate the variance of the test statistic are presented.
Journal ArticleDOI
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.
Kenneth K. Tanabe,Antoinette Lemoine,Dianne M. Finkelstein,Hiroshi Kawasaki,Tsutomu Fujii,Raymond T. Chung,Gregory Y. Lauwers,Yakup Kulu,Alona Muzikansky,Darshini Kuruppu,Michael Lanuti,Jonathan M. Goodwin,Daniel Azoulay,Bryan C. Fuchs +13 more
TL;DR: The EGF gene polymorphism genotype is associated with risk for development of hepatocellular carcinoma in liver cirrhosis through modulation of EGF levels through inhibition fragment-length polymorphism.
Journal ArticleDOI
Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models
TL;DR: The neurobiological mechanisms underlying schizophrenia and novel antipsychotic candidates based on the cytokine hypothesis are discussed, which supports the hypothesis that cytokines transmit peripheral immune/inflammatory signals to immature brain tissue through the developing blood–brain barrier.
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VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis
TL;DR: The T allele of VEGF in +936 may act as a protective allele in the development of PsA and further studies regarding the role of pro-angiogenic markers in PsA are warranted.
References
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Autocrine and paracrine regulation by cytokines and growth factors in melanoma
TL;DR: Understanding the involvement of different growth factors and cytokines in the molecular mechanism of melanoma progression will help to provide an insight into new future therapeutic approaches for melanoma.
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Metabolism and effects of epidermal growth factor and related growth factors in mammals.
TL;DR: EGF has been implicated in a number of developmental events including palate and skin differentiation, growth of hair follicles, eye opening and tooth eruption, lung maturation, gut and liver growth, and differentiation of neurons.
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The Asp84Glu Variant of the Melanocortin 1 Receptor (MC1R) is Associated with Melanoma
Paloma Valverde,Eugene Healy,Stephen Sikkink,Faye Haldane,Anthony J. Thody,Andrew D. Carothers,Ian J. Jackson,Jonathan L. Rees +7 more
TL;DR: Variants of the MC1R gene are likely to be causally associated with the development of melanoma, and the Asp84Glu variant was only present in melanoma cases and appears to be of particular significance.
Journal Article
Characteristics of Cultured Human Melanocytes Isolated from Different Stages of Tumor Progression
Meenhard Herlyn,Jan Thurin,Gloria Balaban,Jeannette L. Bennicelli,Dorothee Herlyn,David E. Elder,Edward E. Bondi,DuPont Guerry,P Nowell,Clark Wh +9 more
TL;DR: Cultured human melanocytic cells appear to be a unique model for the study of tumor progression as exhibited and maintained phenotypic differences when grown in tissue culture or in experimental animals.
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Structure-function relationships for the EGF/TGF-alpha family of mitogens.
TL;DR: The available binding data indicate that the receptor interaction surface for EGF/TGF-alpha might encompass one complete side of the molecule with a few strong binding determinants, in particular Arg41 and Leu47, which seems unlikely that agonists or antagonists can be developed on the basis of short peptides taken from the primary sequence.