T
Toshiyuki Someya
Researcher at Niigata University
Publications - 351
Citations - 8069
Toshiyuki Someya is an academic researcher from Niigata University. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 45, co-authored 336 publications receiving 7236 citations. Previous affiliations of Toshiyuki Someya include Shiga University of Medical Science & Fujita Health University.
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Journal ArticleDOI
Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients.
M. Takahashi,Osamu Shirakawa,Kazuhiko Toyooka,Noboru Kitamura,Takeshi Hashimoto,Kiyoshi Maeda,S Koizumi,Koichi Wakabayashi,Hitoshi Takahashi,Toshiyuki Someya,Hiroyuki Nawa +10 more
TL;DR: Levels of neurotrophins and their receptors in the postmortem brains of schizophrenic patients and control subjects in relation to molecular impairments in schizophrenia suggest that neurotrophic abnormality is associated with the corticolimbic structures of schizophrenia and might provide the molecular substrate for pathological manifestations of the illness.
Journal ArticleDOI
Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients.
Kazuhiko Toyooka,Koue Asama,Yuichiro Watanabe,Tatsuyuki Muratake,Makoto Takahashi,Toshiyuki Someya,Hiroyuki Nawa +6 more
TL;DR: The BDNF reduction in serum but not in whole blood suggests a potential deficit in neurotrophic factor release in patients with schizophrenia, and this study assessed peripheral BDNF levels in whole and serum of schizophrenic patients and healthy volunteers.
Journal ArticleDOI
Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models
TL;DR: The neurobiological mechanisms underlying schizophrenia and novel antipsychotic candidates based on the cytokine hypothesis are discussed, which supports the hypothesis that cytokines transmit peripheral immune/inflammatory signals to immature brain tissue through the developing blood–brain barrier.
Journal ArticleDOI
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights
Itaru Kushima,Branko Aleksic,Masahiro Nakatochi,Teppei Shimamura,Takashi Okada,Yota Uno,Yota Uno,Mako Morikawa,Kanako Ishizuka,Tomoko Shiino,Hiroki Kimura,Yuko Arioka,Akira Yoshimi,Yuto Takasaki,Yanjie Yu,Yukako Nakamura,Maeri Yamamoto,Tetsuya Iidaka,Shuji Iritani,Toshiya Inada,Nanayo Ogawa,Emiko Shishido,Youta Torii,Naoko Kawano,Yutaka Omura,Toru Yoshikawa,Tokio Uchiyama,Toshimichi Yamamoto,Masashi Ikeda,Ryota Hashimoto,Hidenaga Yamamori,Yuka Yasuda,Toshiyuki Someya,Yuichiro Watanabe,Jun Egawa,Ayako Nunokawa,Masanari Itokawa,Makoto Arai,Mitsuhiro Miyashita,Akiko Kobori,Michio Suzuki,Tsutomu Takahashi,Masahide Usami,Masaki Kodaira,Kyota Watanabe,Tsukasa Sasaki,Hitoshi Kuwabara,Mamoru Tochigi,Fumichika Nishimura,Hidenori Yamasue,Yosuke Eriguchi,Seico Benner,Masaki Kojima,Walid Yassin,Toshio Munesue,Shigeru Yokoyama,Ryo Kimura,Yasuko Funabiki,Hirotaka Kosaka,Makoto Ishitobi,Tetsuro Ohmori,Shusuke Numata,Takeo Yoshikawa,Tomoko Toyota,Kazuhiro Yamakawa,Toshimitsu Suzuki,Yushi Inoue,Kentaro Nakaoka,Yu-ichi Goto,Masumi Inagaki,Naoki Hashimoto,Ichiro Kusumi,Shuraku Son,Toshiya Murai,Tempei Ikegame,Naohiro Okada,Kiyoto Kasai,Shohko Kunimoto,Daisuke Mori,Nakao Iwata,Norio Ozaki +80 more
TL;DR: An etiological overlap of ASD and SCZ is suggested and multiple disease-relevant genes in eight well-known ASD/SCZ-associated CNV loci are identified, which provide biological insights into these disorders.
Journal ArticleDOI
Brain Cannabinoid CB2 Receptor in Schizophrenia
Hiroki Ishiguro,Yasue Horiuchi,Maya Ishikawa,Minori Koga,Keiko Imai,Yoshimi Suzuki,Miyuki Morikawa,Toshiya Inada,Yuichiro Watanabe,Makoto Takahashi,Toshiyuki Someya,Hiroshi Ujike,Nakao Iwata,Norio Ozaki,Emmanuel S. Onaivi,Hiroshi Kunugi,Tsukasa Sasaki,Masanari Itokawa,Makoto Arai,Kazuhiro Niizato,Shyuji Iritani,Izumi Naka,Jun Ohashi,Akiyoshi Kakita,Hitoshi Takahashi,Hiroyuki Nawa,Tadao Arinami +26 more
TL;DR: Findings indicate an increased risk of schizophrenia for people with low CB2 receptor function, as well as nominally significant associations between schizophrenia and two SNPs.