Journal ArticleDOI
Association of vitamin D status with serum androgen levels in men.
Elisabeth Wehr,Stefan Pilz,Bernhard O. Boehm,Winfried März,Winfried März,Barbara Obermayer-Pietsch +5 more
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TLDR
This work aimed to investigate the association of 25‐hydroxyvitamin D levels with testosterone, free androgen index (FAI) and SHBG, and examined whether androgen levels show a similar seasonal variation to 25(OH)D.Abstract:
Summary
Objective Studies in rodents indicate a role of vitamin D in male reproduction, but the relationship between vitamin D and androgen levels in men is largely unexplored. We aimed to investigate the association of 25-hydroxyvitamin D [25(OH)D] levels with testosterone, free androgen index (FAI) and SHBG. Moreover, we examined whether androgen levels show a similar seasonal variation to 25(OH)D.
Design In this cross-sectional study, 25(OH)D, testosterone and SHBG levels were assessed by immunoassay in 2299 men who were routinely referred for coronary angiography (1997–2000).
Measurements Main outcome measures were associations of 25(OH)D levels with testosterone, SHBG and FAI. FAI was calculated as testosterone (nmol/l)/SHBG (nmol/l) × 100.
Results Men with sufficient 25(OH)D levels (≥30 μg/l) had significantly higher levels of testosterone and FAI and significantly lower levels of SHBG when compared to 25(OH)D insufficient (20–29·9 μg/l) and 25(OH)D-deficient (<20 μg/l) men (P < 0·05 for all). In linear regression analyses adjusted for possible confounders, we found significant associations of 25(OH)D levels with testosterone, FAI and SHBG levels (P < 0·05 for all). 25(OH)D, testosterone and FAI levels followed a similar seasonal pattern with a nadir in March (12·2 μg/l, 15·9 nmol/l and 40·8, respectively) and peak levels in August (23·4 μg/l, 18·7 nmol/l and 49·7, respectively) (P < 0·05 for all).
Conclusion Androgen levels and 25(OH)D levels are associated in men and reveal a concordant seasonal variation. Randomized controlled trials are warranted to evaluate the effect of vitamin D supplementation on androgen levels.read more
Citations
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Journal ArticleDOI
Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—A review of recent evidence☆
Paweł Płudowski,Michael F. Holick,Stefan Pilz,Stefan Pilz,Carol L. Wagner,Bruce W. Hollis,William B. Grant,Yehuda Shoenfeld,Elisabeth Lerchbaum,David J. Llewellyn,Katharina Kienreich,Maya Soni +11 more
TL;DR: Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for the spectrum of disorders.
Journal ArticleDOI
Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society
Paul Lips,Kevin D. Cashman,Christel Lamberg-Allardt,Heike A. Bischoff-Ferrari,Barbara Obermayer-Pietsch,Maria Luisa Bianchi,Jan J. Stepan,Ghada El-Hajj Fuleihan,Roger Bouillon +8 more
TL;DR: The European Calcified Tissue Society (ECTS) as mentioned in this paper recommends that the measurement of serum 25-hydroxyvitamin D (25(OH)D) be standardized, for example, by the Vitamin D Standardization Program.
Journal ArticleDOI
Vitamin D and fertility: a systematic review.
TL;DR: Evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS) is presented and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in women.
Journal ArticleDOI
The Unitary Model for Estrogen Deficiency and the Pathogenesis of Osteoporosis: Is a Revision Needed?
TL;DR: The original model for the pathogenesis of osteoporosis requires modification but not revision is concluded, leading to a conclusion that a significant proportion of trabecular bone loss is either estrogen‐independent or, as suggested by some studies, requires higher levels for its regulation.
References
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Journal ArticleDOI
Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
TL;DR: Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
Journal ArticleDOI
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Roger Bouillon,Geert Carmeliet,Lieve Verlinden,Evelyne van Etten,Annemieke Verstuyf,Hilary F. Luderer,Liesbet Lieben,Chantal Mathieu,Marie B. Demay +8 more
TL;DR: The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the Vitamin D receptor (VDR).
Journal ArticleDOI
Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials
Philippe Autier,Sara Gandini +1 more
TL;DR: In this paper, the authors examined the risk of dying from any cause in subjects who participated in randomized trials testing the impact of vitamin D supplementation (ergocalciferol [vitamin D 2 ] or cholecalciferols [v vitamin D 3 ]) on any health condition.
Journal ArticleDOI
The effect of finasteride in men with benign prostatic hyperplasia. The Finasteride Study Group.
Glenn J. Gormley,Elizabeth Stoner,Reginald C. Bruskewitz,Julianne Imperato-McGinley,Patrick C. Walsh,John D. McConnell,Gerald L. Andriole,Jack Geller,Bruce Bracken,J S Tenover +9 more
TL;DR: The effect of finasteride (1 mg and 5 mg) on prostate hyperplasia was evaluated in 895 men with prostate cancer in a double-blind study as discussed by the authors.
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