Journal ArticleDOI
Autografting for patients with CML in chronic phase: an update. Hammersmith BMT Team LRF Centre for Adult Leukaemia.
TLDR
If the benefits of autografting in chronic phase seen in this non‐randomized series can be confirmed in a randomized study, autogRAFTing might be the treatment of choice for younger CML patients who do not have suitable donors for allogeneic transplant.Abstract:
Between 1984 and 1992, 21 patients with chronic myeloid leukaemia (CML) in chronic phase (CP) were treated with high-dose chemotherapy (or chemoradiotherapy) followed by autografting with unmanipulated peripheral blood stem cells (PBSC). 12 of these patients survive at a median of 82 months from the time of autografting (range 9-105 months). Nine patients died, six of leukaemia in transformation and three from other causes. Survival of these 21 autograft patients was compared to that of 636 age-matched controls on the Medical Research Council's (MRC) data base, who had been treated with conventional chemotherapy over the same period. Autografted patients had a significantly longer survival at 5 years post autograft than chemotherapy patients (56% v 28%) even after appropriate allowance for time at risk before autograft (Mantel-Byar, 2P = 0.003). There was no difference in survival whether autografting was performed early in the disease or later or whether the PBSC had been harvested soon after diagnosis or later. If the benefits of autografting in chronic phase seen in this non-randomized series can be confirmed in a randomized study, autografting might be the treatment of choice for younger CML patients who do not have suitable donors for allogeneic transplant.read more
Citations
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Journal ArticleDOI
Chronic Myelogenous Leukemia
TL;DR: Through rational drug development, STI571, a bcr-abl tyrosine kinase inhibitor, has emerged as targeted therapy that offers new hope for expanded treatment options for patients with CML.
Journal ArticleDOI
Treatment of Chronic Myelogenous Leukemia: Current Status and Investigational Options
TL;DR: This review of several important studies related to the treatment of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia have matured and suggest therapeutic approaches in the community-based and investigational settings.
Journal ArticleDOI
Autologous transplants for chronic myelogenous leukaemia: results from eight transplant groups
P B McGlave,P De Fabritiis,A Deisseroth,JohnM. Goldman,M Barnett,Josy Reiffers,B Simonsson,A. M. Carella,D Aeppli +8 more
TL;DR: This is the first multicentre analysis of autologous transplants for CML and reports on the largest number of patients studied to date, showing that autologus transplants provide a plateau in the survival curve not observed in conventional treatments.
Journal ArticleDOI
Expansion of Philadelphia Chromosome–Negative CD3+CD56+ Cytotoxic Cells From Chronic Myeloid Leukemia Patients: In Vitro and In Vivo Efficacy in Severe Combined Immunodeficiency Disease Mice
Christine F. Hoyle,Christine F. Hoyle,Charles D. Bangs,Charles D. Bangs,Pearl Chang,Pearl Chang,Onsi W. Kamel,Onsi W. Kamel,Bela A. Mehta,Bela A. Mehta,Robert S. Negrin,Robert S. Negrin +11 more
TL;DR: This study shows that CIK cells, which are Ph chromosome-negative, can be expanded from patients with CML and have potent in vitro and in vivo efficacy against autologous tumor cells.
Journal ArticleDOI
Autografting with philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia.
Angelo Michele Carella,Enrica Lerma,Maria Teresa Corsetti,A. Dejana,Palmina Basta,F Vassallo,Monica Abate,M. Soracco,Federica Benvenuto,O. Figari,Marina Podestà,Giovanna Piaggio,Raimondo Ferrara,Mario Sessarego,Caterina Parodi,Michele Pizzuti,Alessandra Rubagotti,Domenico Occhini,Francesco Frassoni +18 more
TL;DR: Autografting with Ph-negative mobilized HPC can result in prolonged restoration of Ph- negative hematopoiesis for some patients with CML; moreover, most autograft recipients report normal or near normal activity levels, suggesting that this procedure need not to be associated either with prolonged convalescence or with chronic debility.
References
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