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B-Type Natriuretic Peptide (BNP) and Left Ventricular (LV) Function in Patients with ST-Segment Elevation Myocardial Infarction (STEMI).
Maria Dorobantu,Ana-Gabriela Fruntelata,Alexandru Scafa-Udriste,O. Tautu +3 more
- Vol. 5, Iss: 4, pp 243-249
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TLDR
Early measurement of BNP levels may allow early prediction of anterior STEMI patients at risk of developing systolic LV dysfunction after revascularization therapy, and show no predictive value for diastolic LV function in anteior or inferior AMI patients.Abstract:
Background: After acute myocardial infarction (AMI), left ventricular (LV) function is a well-established prognostic marker. Recent studies indicate that serum levels of brain natriuretic peptide (BNP) also represent an prognostic marker in this setting but so far without a precise cut-off value.
Objective: The aim of this study was to assess the predictive value of BNP serum levels for LV function assessed by echocardiography in STEMI patients undergoing revascularization.
Methods: We prospectively studied a cohort of 88 consecutive patients (mean age 51.6 years, 88.6% males) hospitalized in our clinic for STEMI in Killip class I (50% anterior infarction), who underwent reperfusion therapy. Serum BNP levels were measured on admission, at 24h and at 30 days after reperfusion. Detailed echocardiography was performed at baseline, at 24 hours after reperfusion, on discharge and at follow-up at 1 month. Left ventricular systolic and diastolic dysfunction were defined by LVEF < 45% and E/A ratio respectively.
Results: ROC curve analysis showed that BNP measurements on admission and at 24 hours after revascularization have no predictive value neighter for diastolic LV dysfunction in anteior or inferior AMI patients, nor for systolic LV dysfunction in inferior AMI patients. Only BNP levels at 24 hours after revascularization can predict systolic LV dysfunction in anterior AMI patients with a 90.3% sensitivity and a 60% false positive rate at a cutt off value of 90pg/ml.
Conclusions: Early measurement of BNP levels may allow early prediction of anterior STEMI patients at risk of developing systolic LV dysfunction after revascularization therapy.read more
Citations
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Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure
D. Muthu,T. Elavazhagan +1 more
TL;DR: To measure BNP levels in Patients with congestive heart disease, to use the BNP in the heart failure treatment and Routine use of BNP assays may help to more rapidly identify patients with heart failure, thereby saving money on unnecessary echocardiograms.
Journal ArticleDOI
Administration of a Loading Dose of Atorvastatin Before Percutaneous Coronary Intervention Prevents Inflammation and Reduces Myocardial Injury in STEMI Patients: A Randomized Clinical Study
TL;DR: Loading-dose atorvastatin therapy before emergency PCI reduced the inflammatory response and myocardial dysfunction in these STEMI patients by lowering hs-CRP, BNP, and MMP-9.
Journal ArticleDOI
Electrochemical-Based Biosensors: New Diagnosis Platforms for Cardiovascular Disease.
Fatemeh Yousefi,Ahmad Movahedpour,Zahra Shabaninejad,Younes Ghasemi,Shahram Rabbani,Ali Sobnani-Nasab,Soheila Mohammadi,Behzad Hajimoradi,Samaneh Rezaei,Amir Savardashtaki,Majid Mazoochi,Hamed Mirzaei +11 more
TL;DR: The present review comprehensively dealt with detecting biomarkers of cardiovascular disease through electro-chemical techniques and the proposed bio-sensors are preferred over other methods due to its inexpensiveness, mobility, reliability, repeatability.
Journal ArticleDOI
Predictors of left ventricle remodeling: Combined plasma B-type natriuretic peptide decreasing ratio and peak creatine kinase-MB
Jen-Te Hsu,Chang-Min Chung,Chi-Ming Chu,Yu-Shen Lin,Kuo-Li Pan,Jung-Jung Chang,Po-Chang Wang,Shih-Tai Chang,Teng-Yao Yang,Shih-Jung Jang,Tsung-Han Yang,Ju-Feng Hsiao +11 more
TL;DR: RBNP 13 is a significant independent predictor of 6-month LV remodeling, and combining peak CK-MB and RBNP13 offered an excellent discrimination for half-year remodeling when assessed by ROC curve.
B-Type Natriuretic Peptide and Intraventricular Conduction Delay in Idiopathic Nonischemic Dilated Cardiomyopathy
TL;DR: Increased plasma BNP levels may facilitate the diagnosis of INIDCM and may be associated with high IVCD.
References
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TL;DR: The results seen with primary PTCA remained better than those seen with thrombolytic therapy during long-term follow-up, and were independent of both the type of throm bolytic agent used and whether or not the patient was transferred for primary P TCA.
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Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.
Alan S. Maisel,Padma Krishnaswamy,Richard M. Nowak,James McCord,Judd E. Hollander,Philippe Duc,Torbjørn Omland,Alan B. Storrow,William T. Abraham,Alan H.B. Wu,Paul Clopton,Philippe Gabriel Steg,Arne Westheim,Catherine W. Knudsen,Alberto Perez,Radmila Kazanegra,Howard C. Herrmann,Peter A. McCullough +17 more
TL;DR: Used in conjunction with other clinical information, rapid measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
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Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure.
Hirofumi Yasue,Michihiro Yoshimura,Hitoshi Sumida,Koichi Kikuta,Kiyotaka Kugiyama,Michihisa Jougasaki,Hisao Ogawa,Ken Okumura,Masashi Mukoyama,Kazuwa Nakao +9 more
TL;DR: Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction.
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The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes.
James A. de Lemos,David A. Morrow,Jane H. Bentley,Torbjørn Omland,Marc S. Sabatine,Carolyn H. McCabe,Christian Hall,Christopher P. Cannon,Eugene Braunwald +8 more
TL;DR: A single measurement of B-type natriuretic peptide, obtained in the first few days after the onset of ischemic symptoms, provides powerful information for use in risk stratification across the spectrum of acute coronary syndromes, and suggests that cardiac neurohormonal activation may be a unifying feature among patients at high risk for death after acute coronary syndrome.
Journal ArticleDOI
B-type natriuretic peptide in cardiovascular disease
TL;DR: Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on.