Bacteriophage receptors, mechanisms of phage adsorption and penetration into host cell.
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TLDR
Structures governing phage recognition of host cell and mechanisms of phage adsorption and penetration into microbial cell are reviewed.Abstract:
Bacteriophages are an attractive tool for application in the therapy of bacterial infections, for biological control of bacterial contamination of foodstuffs in the alimentary industry, in plant protection, for control of water-borne pathogens, and control of environmental microflora. This review is mainly focused on structures governing phage recognition of host cell and mechanisms of phage adsorption and penetration into microbial cell.read more
Citations
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Type VI secretion delivers bacteriolytic effectors to target cells
Alistair B. Russell,Rachel D. Hood,Nhat Khai Bui,Michele LeRoux,Waldemar Vollmer,Joseph D. Mougous +5 more
TL;DR: It is shown that the type VI secretion system of Pseudomonas aeruginosa breaches this barrier to deliver two effector proteins, Tse1 and Tse3, to the periplasm of recipient cells, indicating a mechanism for export whereby effectors do not access donor cellperiplasm in transit.
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Revenge of the phages: defeating bacterial defences
TL;DR: The various tactics that are used by phages to overcome bacterial resistance mechanisms, including adsorption inhibition, restriction–modification, CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems and abortive infection are described.
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Phage therapy: An alternative to antibiotics in the age of multi-drug resistance.
TL;DR: Current research on the use of phages and their lytic proteins, specifically against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments.
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Host receptors for bacteriophage adsorption
TL;DR: An open-access resource, the Phage Receptor Database (PhReD), is established to serve as a repository for information on known and newly identified phage receptors involved in recognition and adsorption and their interactions during attachment.
Journal ArticleDOI
Understanding bacteriophage specificity in natural microbial communities.
Britt Koskella,Sean Meaden +1 more
TL;DR: There is currently insufficient evidence to make broad generalizations about phage host range in natural populations, the limits of phages adaptation to novel hosts, or the implications of phage specificity in shaping microbial communities, but the combination of experimental and genomic approaches with the study of natural communities will allow new insight to the evolution and impact ofphage specificity within complex bacterial communities.
References
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Isolation of the Bacteriophage Lambda Receptor from Escherichia coli
TL;DR: A factor which inactivates the phage lambda can be extracted from Escherichia coli and is concluded that this factor is the lambda receptor, responsible for the specific adsorption of thephage lambda to E. coli cells.