Journal ArticleDOI
Behavioral effects of lesions or cholinergic blockade of the dorsal and ventral caudate of rats.
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This article is published in Journal of Comparative and Physiological Psychology.The article was published on 1970-05-01. It has received 126 citations till now.read more
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Cholinergic blockade of the caudate nucleus and spatial alternation performance in rats: overtraining induced protection against behavioral deficits.
Roberto A. Prado-Alcalá,Federico Bermúdez-Rattoni,David N. Velasquez-Martínez,M Gustavo Bacha +3 more
TL;DR: Results reveal that in both simple and complex learned behaviors overtraining induces protection againts performance decrements.
Journal ArticleDOI
Elimination of learned behaviors after transection of fibers crossing the lateral border of the hypothalamus
TL;DR: A wire knife operated through a hypodermic needle was used to sever the fibers which cross the lateral border of the diencephalon in rats, eliminating or significantly impaired the performance of a variety of learned behaviors rewarded by electrical brain stimulation, escape from footshock, or food, and retarded the acquisition or reacquisition of these behaviors.
Journal ArticleDOI
Is cholinergic activity of the striatum involved in the acquisition of positively-motivated behaviors?
TL;DR: It was found that scopolamine injection into either region of the CPU produced a marked retardation in the acquisition of the conditioned behavior, indicating that cholinergic activity of the striatum is critically involved in the early phases of positively-reinforced learning.
Journal ArticleDOI
Scopolamine and KCl injections into the caudate nucleus. Overtraining-induced protection against deficits of learning.
Roberto A. Prado-Alcalá,Roberto A. Prado-Alcalá,Patricia Kaufmann,Patricia Kaufmann,Renee Moscona,Renee Moscona +5 more
TL;DR: Results show that normal neural activity of the CN is essential for performance of instrumental behavior during acquisition and early maintenance stages but not after overtraining, and that after extended training the encoding necessary for performance may be transferred to another neural system outside the CN.
Journal ArticleDOI
Effects of intrastriatal injections of the cholinergic neurotoxin AF64A on spontaneous nocturnal locomotor behavior in the rat
TL;DR: The hyperactivity found in these rats after intrastriatal injection of AF64A supports a role for the striatal cholinergic system in locomotor behavior.
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Statistical Principles in Experimental Design
TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
Journal ArticleDOI
Statistical Principles in Experimental Design
TL;DR: This chapter discusses design and analysis of single-Factor Experiments: Completely Randomized Design and Factorial Experiments in which Some of the Interactions are Confounded.
Journal Article
Dopamine (3-hydroxytyramine) and brain function
TL;DR: A good case can be made for the concept that the physiological activity of the brain dopamine is quite different from that of brain norepinephrine, although there are as yet no experiments to positively show that dopamine is a true neuro-transmitter substance in the brain.