Journal ArticleDOI
Bifidobacterium infantis suppression of Peyer's patch MIP-1α and MIP-1β secretion during Salmonella infection correlates with increased local CD4+CD25+ T cell numbers.
Paul Scully,John MacSharry,Denis O'Mahony,Anne Lyons,Frances O'Brien,Sharon Murphy,Fergus Shanahan,Liam O'Mahony +7 more
TLDR
Although B. infantis 35624-induced Tregs correlate with inhibition of chemokine secretion within the mucosa of pathogen infected animals, indirect cellular mechanisms may play a role.About:
This article is published in Cellular Immunology.The article was published on 2013-02-01. It has received 36 citations till now. The article focuses on the topics: Chemokine secretion & Peyer's patch.read more
Citations
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Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence.
TL;DR: The immunological mechanisms underpinning probiotics, prebiotics, and synbiotics effects continue to be better defined with novel mechanisms being described for dendritic cells, epithelial cells, T regulatory cells, effector lymphocytes, natural killer T cells, and B cells.
Journal ArticleDOI
The Influence of Early Infant-Feeding Practices on the Intestinal Microbiome and Body Composition in Infants.
TL;DR: The case is made for the need to conduct well-designed studies on mixed-feeding before it can truly answer the question: how does brief or long-term use of formula influence the health benefits of exclusive breastfeeding.
Journal ArticleDOI
The Surface-Associated Exopolysaccharide of Bifidobacterium longum 35624 Plays an Essential Role in Dampening Host Proinflammatory Responses and Repressing Local TH17 Responses.
Elisa Schiavi,Marita Gleinser,Evelyn M. Molloy,David Groeger,Remo Frei,Ruth Ferstl,Noelia Rodriguez-Perez,Mario Ziegler,Ray Grant,Thomas Fintan Moriarty,Stephan Plattner,Selena Healy,Mary O'Connell Motherway,Cezmi A. Akdis,Jennifer Roper,Friedrich Altmann,Douwe van Sinderen,Liam O'Mahony +17 more
TL;DR: The data demonstrate that the particular exopolysaccharide produced by B. longum 35624 plays an essential role in dampening proinflammatory host responses to the strain and that loss of exopoly Saccharide production results in the induction of local TH17 responses.
Journal ArticleDOI
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
TL;DR: The probiotic combination VSL#3 may be effective in inducing remission in patients with mild‐to‐moderate ulcerative colitis, in whom Escherichia coli Nissle 1917 seems to be as effective as mesalamine in maintaining remission.
Journal ArticleDOI
Probiotics in Inflammatory Bowel Disease.
TL;DR: There has been little indication that probiotics exert any benefit in Crohn disease, but more targeted approaches involving live bacteria, genetically modified bacteria, and bacterial products are now being evaluated.
References
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Journal ArticleDOI
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Wanjun Chen,Wenwen Jin,Neil J. Hardegen,Ke Jian Lei,Li Li,Nancy J. Marinos,George McGrady,Sharon M. Wahl +7 more
TL;DR: Novel evidence is presented that conversion of naive peripheral CD4+CD25− T cells into anergic/suppressor cells that are CD25+, CD45RB−/low and intracellular CTLA-4+ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor β (TGF-β).
Journal ArticleDOI
Probiotics in man and animals
TL;DR: In this paper, the authors used probiotic treatments to re-establish the natural condition which exists in the wild animal but which has been disrupted by modern trends in conditions used for rearing young animals, including human babies, and in modern approaches to nutrition and disease therapy.
Journal Article
Probiotics in man and animals
TL;DR: These are all areas where the gut flora can be altered for the worse and where, by the administration of probiotics, the natural balance of the gut microflora can be restored and the animal returned to its normal nutrition, growth and health status.
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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Janine L. Coombes,Karima R.R. Siddiqui,Carolina V. Arancibia-Cárcamo,Jason A. Hall,Cheng-Ming Sun,Yasmine Belkaid,Fiona Powrie +6 more
TL;DR: It is shown that after antigen activation in the intestine, naive T cells acquire expression of Foxp3, and RA is identified as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine.
Journal ArticleDOI
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Cheng-Ming Sun,Jason A. Hall,Jason A. Hall,Rebecca Blank,Nicolas Bouladoux,Mohamed Oukka,J. Rodrigo Mora,Yasmine Belkaid +7 more
TL;DR: It is shown that peripheral conversion of CD4+ T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) after oral exposure to antigen and in a lymphopenic environment, and that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.