Journal ArticleDOI
Binding of mercury in the rat kidney by metallothionein
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TLDR
Metallothionein is identified as the compound responsible for the selective binding and retention of mercury in the kidney of rats.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 107 citations till now. The article focuses on the topics: Metallothionein & Sephadex.read more
Citations
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Journal ArticleDOI
Metallothionein Cd4S11 cluster formation dominates in the protection of carbonic anhydrase.
TL;DR: The data support the physiological role of MTs as protectors of the metalloproteome from the toxic effects of Cd2+.
Journal ArticleDOI
Mercury toxicokinetics in Wistar rats exposed to elemental mercury vapour: modeling and computer simulation.
TL;DR: A compartmental model was built as a framework for experimental data interpretation and prediction of organ mercury levels under different conditions and exposures of rats under conditions comparable to those of professionally exposed workers and individuals with amalgam fillings were simulated.
Book ChapterDOI
Chapter 2 Exposure to Toxic Metals: Biological Effects and Their Monitoring
TL;DR: In this paper, the authors emphasized the necessity for quality assurance in trace-element analysis, recommending the development and extensive use of quality control materials, as well as inter and intralaboratory evaluations at the national and international level, to establish whether discrepancies in reported values from various laboratories arise from poor methodology, faulty technique, loss of specimen integrity, or other causes.
Journal ArticleDOI
Ultrastructural identification of mercury in epidermis. A method for visualization of gold-mercury amalgams in skin from normal and allergic persons and those with primary irritant reactions to mercury.
TL;DR: Differences in mercury localization were found between clinically normal patch test reactions and allergic or primary irritant reactions, and the number of specifically localized, larger densities associated with mercury-gold reaction product decreased.
Journal ArticleDOI
Renal cortical mercury distribution following dithiothreitol administration
D R Klonne,D R Johnson +1 more
TL;DR: It is concluded that DTT administration ameliorates the nephrotoxic effect of prior mercury injection by a more subtle mechanism than redistribution of renal cortical mercury.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Estimation of the molecular weights of proteins by Sephadex gel-filtration.
TL;DR: The results are similar to those of previous studies, where the objective was to establish a cause-and-effect relationship, rather than a straightforward relationship between the number of cells and the content of the molecule.
Journal ArticleDOI
The gel-filtration behaviour of proteins related to their molecular weights over a wide range
TL;DR: Correlation between elution volume, V(e), and molecular weight was investigated for gel filtration of proteins of molecular weights ranging from 3500 (glucagon) to 820000 (alpha-crystallin) on Sephadex G-200 columns at pH7.5.