Journal ArticleDOI
Binding of mercury in the rat kidney by metallothionein
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TLDR
Metallothionein is identified as the compound responsible for the selective binding and retention of mercury in the kidney of rats.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 107 citations till now. The article focuses on the topics: Metallothionein & Sephadex.read more
Citations
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Studies on the binding of methylmercury by thionein.
TL;DR: Methylmercury, in contrast to Hg++ and Cd++, was found to have a low affinity for the metal-free form of metallothionein isolated from horse kidney, which appears to have no significant role in the detoxification or body distribution of methylMERcury except to scavenge HG++ formed by the slow biotransformation of methylmercuries in the body.
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Intestinal response to 1α,25,dihydroxycholecalciferol II. A timed study of the intracellular localization of calcium binding protein
TL;DR: It is concluded that both young cells at the base of the villus and more mature cells atThe villus tip are capable of calcium binding protein synthesis, but the young cells respond much faster than the cell migration rate.
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Induction of Metallothionein in HeLa Cells by Dexamethasone and Zinc
TL;DR: Zn2+ and dexamethasone appear to induce metallothionein synthesis in HeLa cells by mechanisms independent of one another, indicating that the two inducers work through independent mechanisms.
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A combined hydraulic and toxicological approach to assess re-suspended sediments during simulated flood events. Part I–multiple biomarkers in rainbow trout
Markus Brinkmann,Sebastian Hudjetz,Catrina Cofalla,Sebastian Roger,Ulrike Kammann,John P. Giesy,John P. Giesy,John P. Giesy,Markus Hecker,Steve Wiseman,Xiaowei Zhang,Jan Wölz,Holger Schüttrumpf,Henner Hollert +13 more
TL;DR: In this article, a proof-of-concept study combining hydraulic engineering and ecotoxicology in a new interdisciplinary approach to assess the toxicity of re-suspended polluted sediments after a simulated flood event was presented.
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Cadmium-induced synthesis of hepatic metallothionein in chicken and rats
TL;DR: Preparation of homogeneous hepatic metallo~ o n e i n as:rag ra~s and cNeken whi'ch were previously injected with Cd, Pree~pitatio n steps employing inorFurthermore, some physieochemical dala like UV absorption, CD properties and X-ray photoelectron spec~m were ~i~ually identical whme~er metallo ~Nonein was examined.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Estimation of the molecular weights of proteins by Sephadex gel-filtration.
TL;DR: The results are similar to those of previous studies, where the objective was to establish a cause-and-effect relationship, rather than a straightforward relationship between the number of cells and the content of the molecule.
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The gel-filtration behaviour of proteins related to their molecular weights over a wide range
TL;DR: Correlation between elution volume, V(e), and molecular weight was investigated for gel filtration of proteins of molecular weights ranging from 3500 (glucagon) to 820000 (alpha-crystallin) on Sephadex G-200 columns at pH7.5.