Journal ArticleDOI
Advances in copper complexes as anticancer agents.
Carlo Santini,Maura Pellei,Valentina Gandin,Marina Porchia,Francesco Tisato,Cristina Marzano +5 more
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This article is published in Chemical Reviews.The article was published on 2014-01-08. It has received 1256 citations till now.read more
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Metal complexes in cancer therapy - an update from drug design perspective.
TL;DR: It is optimistic that the concept of selective targeting remains the hope of the future in developing therapeutics that would selectively target cancer cells and leave healthy cells unharmed in cancer therapy.
Journal ArticleDOI
Targeting copper in cancer therapy: ‘Copper That Cancer’
Delphine Denoyer,Shashank Masaldan,Sharon La Fontaine,Sharon La Fontaine,Michael A. Cater,Michael A. Cater +5 more
TL;DR: The biological importance of copper and copper homeostasis in mammalian cells is outlined, followed by a discussion of the current understanding of copper dysregulation in cancer, and the recent therapeutic advances using copper coordination complexes as anticancer agents.
Journal ArticleDOI
Copper(II)-Graphitic Carbon Nitride Triggered Synergy: Improved ROS Generation and Reduced Glutathione Levels for Enhanced Photodynamic Therapy.
Enguo Ju,Kai Dong,Zhaowei Chen,Zhen Liu,Chaoqun Liu,Yanyan Huang,Zhenzhen Wang,Fang Pu,Jinsong Ren,Xiaogang Qu +9 more
TL;DR: Redox-active species Cu(+) -g-C3 N4 could catalyze the reduction of molecular oxygen to the superoxide anion or hydrogen peroxide to the hydroxyl radical, both of which facilitated the generation of ROS.
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Toward Multi-Targeted Platinum and Ruthenium Drugs-A New Paradigm in Cancer Drug Treatment Regimens?
Reece G. Kenny,Celine J. Marmion +1 more
TL;DR: This review has endeavored to showcase how a "multitargeted" approach to drug design has led to new families of metallodrugs which may not only reduce systemic toxicities associated with modern day chemotherapeutics but also address resistance issues that are plaguing many Chemotherapeutic regimens.
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Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria
TL;DR: These are a collection of approaches that involve ROS modulation in cells as a strategy to target cancer and bacteria and could serve as novel therapeutics.
References
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Metals, toxicity and oxidative stress.
TL;DR: This review summarizes recent findings in the metal-induced formation of free radicals and the role of oxidative stress in the carcinogenicity and toxicity of metals.
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Cellular processing of platinum anticancer drugs.
Dong Wang,Stephen J. Lippard +1 more
TL;DR: This review focuses on recently discovered cellular pathways that are activated in response to cisplatin, including those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle checkpoints and arrest, DNA repair and cell death.
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Heterocyclic Carbenes: Synthesis and Coordination Chemistry
TL;DR: New methods for the synthesis of complexes with N-heterocyclic carbene ligands such as the oxidative addition or the metal atom template controlled cyclized isocyanides have been developed recently.
Book
Principles of bioinorganic chemistry
Stephen J. Lippard,Jeremy M Berg +1 more
TL;DR: An Overview of Bioinorganic Chemistry Principles of Coordination Chemistry Related to bioinorganic Research Properties of Biological Molecules and Physical Methods in Bioin organic Chemistry.