Journal ArticleDOI
Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome.
Aifric O'Sullivan,Michael J. Gibney,Aine O. Connor,B. Mion,Soniya Kaluskar,Kevin D. Cashman,Albert Flynn,Fergus Shanahan,Lorraine Brennan +8 more
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TLDR
Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation, and the extent of change in serum vitamin D correlated negatively with changes in glucose.Abstract:
Scope: Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome.
Methods and results: In a double-blind, randomised placebo-controlled dietary intervention subjects were assigned to receive 15 μg vitamin D3 or placebo daily. Serum 25-hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4-wk intervention. k-means clustering and 1H-NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH)D to an endpoint concentration of 78.1±20.0 nmol/L (p<0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. k-means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH)D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic model assessment scores (19% decrease) and c-reactive protein (54% decrease). Metabolomic analysis revealed further changes and the extent of change in serum vitamin D correlated negatively with changes in glucose.
Conclusion: Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation.read more
Citations
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Journal ArticleDOI
Metabolic Phenotyping and Systems Biology Approaches to Understanding Metabolic Syndrome and Fatty Liver Disease
TL;DR: Recent developments in metabolic phenotyping and systems biology technologies are reviewed and how these methodologies have provided insights into the mechanisms of metabolic syndrome and nonalcoholic fatty liver disease are reviewed.
Relation between 25-hydraxyvitamin D3, apolipoproyein A-I, and high density lipoprotein cholesterol
TL;DR: In a survey of cardiovascular risk factors in 185 men and 173 women of a Belgian population group, an independent and highly significant positive correlation was found between the serum concentrations of 25-hydroxyvitamin D3 and apolipoprotein A-I.
Journal ArticleDOI
The future direction of personalised nutrition: my diet, my phenotype, my genes.
TL;DR: There are significant challenges to translation of data on SNP and diet into personalised advice, but extensive research indicates that consumers would welcome personalised dietary advice including dietary advice based on their genotype.
Journal ArticleDOI
Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials.
TL;DR: Meta‐regression confirmed that neither the absolute vitamin D status achieved nor its change from baseline influenced the SMD of any obesity measure, but increasing age of the subjects predicted a shift in theSMD for FM towards the placebo treatment, whereas a greater percentage of women in these studies favoured a decrease in FM following vitamin D.
ReportDOI
Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update).
Sydne J Newberry,Mei Chung,Paul G. Shekelle,Marika Booth,Jodi L. Liu,Alicia Ruelaz Maher,Aneesa Motala,Mike Cui,Tanja Perry,Roberta M. Shanman,Ethan M Balk +10 more
TL;DR: The current report identified one new systematic review published since the original report that addressed whether a dose response relationship exists between dietary and supplemental vitamin D intake and serum 25(OH)D concentrations.
References
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Journal ArticleDOI
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar,Laila M. Poisson,Thekkelnaycke M. Rajendiran,Amjad Khan,Qi Cao,Jindan Yu,Bharathi Laxman,Rohit Mehra,Robert J. Lonigro,Yong Li,Mukesh K. Nyati,Aarif Ahsan,Shanker Kalyana-Sundaram,Bo Han,Xuhong Cao,Jaeman Byun,Gilbert S. Omenn,Debashis Ghosh,Subramaniam Pennathur,Danny C. Alexander,Alvin Berger,Jeffrey R. Shuster,John T. Wei,Sooryanarayana Varambally,Christopher A. Beecher,Arul M. Chinnaiyan +25 more
TL;DR: Sarcosine, an N-methyl derivative of the amino acid glycine, was identified as a differential metabolite that was highly increased during prostate cancer progression to metastasis and can be detected non-invasively in urine.
Journal ArticleDOI
Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
TL;DR: A positive correlation of 25(OH)D concentration with insulin sensitivity and a negative effect of hypovitaminosis D on beta cell function are shown, which are at higher risk of insulin resistance and the metabolic syndrome.
Hypovitaminosis D is associated with insulin resistance and cell
TL;DR: In this paper, the relation of 25-hydroxyvitamin D [25(OH)D] concentrations to insulin sensitivity and cell function was investigated, and the results showed that 25-OHD concentration was positively correlated with ISI (P 0.0001) and negatively correlated with 1st and second-phase insulin responses (1stIR and 2ndIR).
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