Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and foreign body response-part II: examples and application.
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This article is the second part of a two-part review in which the biomechanics of the sensor-tissue interface is explored as an important aspect of continuous glucose sensor biocompatibility.Abstract:
This article is the second part of a two-part review in which we explore the biomechanics of the sensor–tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I, featured in this issue of Journal of Diabetes Science and Technology, describes a theoretical framework of how biomechanical factors such as motion and pressure (typically micromotion and micropressure) affect tissue physiology around a sensor and in turn, impact sensor performance. Here in Part II, a literature review is presented that summarizes examples of motion or pressure affecting sensor performance. Data are presented that show how both acute and chronic forces can impact continuous glucose monitor signals. Also presented are potential strategies for countering the ill effects of motion and pressure on glucose sensors. Improved engineering and optimized chemical biocompatibility have advanced sensor design and function, but we believe that mechanical biocompatibility, a rarely considered factor, must also be optimized in order to achieve an accurate, long-term, implantable sensor.read more
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Journal ArticleDOI
Biocompatible materials for continuous glucose monitoring devices.
TL;DR: Progress is described in the development of continuous glucose monitoring technologies, specifically focusing on subcutaneous implantable electrochemical glucose sensors, which are widely studied and commercially available and are linked to an insulin delivery pump, creating an artificial pancreas.
Journal ArticleDOI
Challenges and Recent Progress in the Development of a Closed-loop Artificial Pancreas
TL;DR: Meals cause a major "disturbance" to blood glucose, and techniques that this group has developed to predict when a meal is likely to be consumed and its effect are discussed.
Journal ArticleDOI
A comparative effectiveness analysis of three continuous glucose monitors: the Navigator, G4 Platinum, and Enlite.
Edward R. Damiano,Katherine McKeon,El-Khatib Firas H,Hui Zheng,David M. Nathan,Steven Russell +5 more
TL;DR: The Navigator and G4 were found to outperform the Enlite in these areas of accuracy and precision, and all 3 devices had similar reliability.
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American association of clinical endocrinologists and american college of endocrinology 2016 outpatient glucose monitoring consensus statement.
Timothy S. Bailey,George Grunberger,Bruce W. Bode,Yehuda Handelsman,Irl B. Hirsch,Lois Jovanovič,Victor L. Roberts,David Rodbard,William V. Tamborlane,John Walsh +9 more
TL;DR: This document represents the official position of the American Association of Clinical Endocrinologists and American College of Endocrinology and it is not to be considered prescriptive for any individual patient and cannot replace the judgment of a clinician.
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Bioinspired water-enhanced mechanical gradient nanocomposite films that mimic the architecture and properties of the squid beak.
TL;DR: A nanocomposite that mimics both the architecture and properties of this interesting natural material, and it is shown that the wet modulus can be controlled by altering the UV exposure time which allows access to mechanical gradient films.
References
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Journal ArticleDOI
Biological Responses to Materials
TL;DR: The in vivo evaluation of tissue responses to biomaterials, medical devices, and prostheses to determine intended performance characteristics and safety or biocompatibility considerations is described.
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A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
TL;DR: It is proposed that the osteocytes, although not responsive to substantial fluid pressures, can be stimulated by relatively small fluid shear stresses acting on the membranes of their osteocytic processes.
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The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials
TL;DR: The methods presented in this paper can be used to establish optimal stem-design characteristics or check the adequacy of designs in preclinical testing procedures.
Journal ArticleDOI
Timing of loading and effect of micromotion on bone-dental implant interface: review of experimental literature
TL;DR: Whether this no-load healing period is validated by the experimental literature is examined, which suggests that there is a critical threshold of micromotion above which fibrous encapsulation prevails over osseointegration, and suggestions are made for the earliest loading time that achieves osseointedegration.
Journal ArticleDOI
Mechanical Properties and Young's Modulus of Human Skin in Vivo
TL;DR: The experiment performed on 138 individuals revealed a diminished elasticity and stretchability after the age of 30, associated with an increase in the visco-elastic component.
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