Journal ArticleDOI
Biosynthesis of the indole alkaloids
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This article is published in Accounts of Chemical Research.The article was published on 1970-05-01. It has received 176 citations till now. The article focuses on the topics: Indole test.read more
Citations
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Journal ArticleDOI
Chemistry and biology of monoterpene indole alkaloid biosynthesis
TL;DR: The biosynthetic pathways for several representative terpene indole alkaloids are described in detail, showing a diverse array of structures and biological activities.
Book ChapterDOI
Formation of the Indole Alkaloids Serpentine and Ajmalicine in Cell Suspension Cultures of Catharanthus roseus
TL;DR: Since there is an overall shortage of Rauwolfia drugs, increasing use is being made of the serpentine reduction method, and in roots of the fast growing Catharanthus roseus low amounts of ajmalicine, but relatively large amounts of serpentine are produced.
Journal ArticleDOI
Intramolecular [4+2] and [3+2] Cycloadditions in Organic Synthesis
Book ChapterDOI
Hetero diels-alder reactions in organic chemistry
Lutz F. Tietze,Georg Kettschau +1 more
TL;DR: In this article, an overview is given for the period since 1989 describing the reaction of heterobutadienes and other dienophiles such as carbonyls, thiocarbonyls and iminium salts.
Journal ArticleDOI
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle
Lorenzo Caputi,Jakob Franke,Scott C. Farrow,Khoa Chung,Richard M. E. Payne,Trinh-Don Nguyen,Thu-Thuy T. Dang,Inês Carqueijeiro,Konstantinos Koudounas,Thomas Dugé de Bernonville,Belinda Ameyaw,D. Marc Jones,Ivo Jose Curcino Vieira,Vincent Courdavault,Sarah E. O'Connor +14 more
TL;DR: Two missing enzymes necessary for vinblastine biosynthesis in this plant are identified: an oxidase and a reductase that isomerize stemmadenine acetate into dihydroprecondylocarpine acetates, which is then deacetoxylated and cyclized to either catharanthine or tabersonine via two hydrolases characterized herein.
References
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Journal ArticleDOI
A uniform numbering system for indole alkaloids.
TL;DR: Nous proposons un mode uniforme de numérotation pour le squelette des alcaloïdes indoliques complexes complexes d'être coupés en éléments identiques.
Journal ArticleDOI
Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) V.: Preparation and Characterization of Alkaloids
TL;DR: A detailed phytochemical investigation of the pantropical plant Vinca rosea Linn is undertaken, finding two alkaloids, leurosine and vincaleukoblastine, possess activity against P-1534 leukemia in mice.