Journal ArticleDOI
Biphasic vesicles for topical delivery of interferon alpha in human volunteers and treatment of patients with human papillomavirus infections.
Marianna Foldvari,Ildiko Badea,Praveen Kumar,Shawn D. Wettig,Ravinder Batta,Martin J. King,Zhihong He,Emmanuel Yeboah,Kimberly J Gaspar,Peter R. Hull,Neil H. Shear +10 more
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TLDR
Biphasic vesicles delivered clinically significant levels of IFN α across intact human skin and elicited marked therapeutic effect in patients, and was developed as an alternative to injections used to treat human papillomavirus (HPV) infections.Abstract:
PURPOSE. Topical biphasic vesicle delivery system encapsulating interferon alpha (IFN α) was developed as an alternative to injections used to treat human papillomavirus (HPV) infections. METHODS. Biphasic lipid vesicles encapsulating increasing doses of IFN α (biphasic IFN α) were characterized for encapsulation efficiency, size, zeta potential and vesicle structure by centrifugation, dynamic light scattering, confocal microscopy and small-angle x-ray scattering. Biphasic IFN-α delivery into human skin in vivo and topical efficacy in patients with genital warts were evaluated. RESULTS. Average encapsulation efficiency of IFN α was 81-91%. The average particle size was 1000-1100 nm and zeta potential +70 to +78 mV. After application of 5, 15 and 40MU/g biphasic IFN α formulation in a topical patch on the upper inner arm in healthy volunteers, skin IFN α levels increased to 120±30, 380±60 and 400±80 IU/mg protein in skin homogenates (n=5, 5, and 7), respectively. Topical application of biphasic IFN α (1 MU/dose) twice daily for two weeks in a pilot study with 12 patients with external condylomata acuminata resulted in a decrease in lesion size, in 2',5'-oligoadenylate synthetase activity and in tissue viral load. CONCLUSIONS. Biphasic vesicles delivered clinically significant levels of IFN α across intact human skin and elicited marked therapeutic effect in patients.read more
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Permeation enhancer strategies in transdermal drug delivery
TL;DR: New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for thetransdermal delivery of troublesome drugs.
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PEGylated liposomes for topical vaginal therapy improve delivery of interferon alpha
May Wenche Jøraholmen,Purusotam Basnet,Purusotam Basnet,Ganesh Acharya,Ganesh Acharya,Ganesh Acharya,Nataša Škalko-Basnet +6 more
TL;DR: Mulin studies confirmed the absence of interaction between the PEG‐modified liposomes and mucin, confirming their ability to penetrate mucus and reach the deeper epithelium, and the system holds a promise in improving topical delivery of IFN &agr;‐2b through enhanced efficacy of local anti‐viral therapy.
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Ultradeformable archaeosomes as new topical adjuvants
Leticia Herminia Higa,Priscila Schilrreff,Ana Beatriz Alvarez Perez,Maiara A. Iriarte,Diana I. Roncaglia,Maria Jose Morilla,Eder Lilia Romero +6 more
TL;DR: Key findings related to the development of ultradeformable archaeosomes as vehicles utilized in transdermal delivery systems with improved skin penetration are summarized.
Journal ArticleDOI
Highlights in nanocarriers for the treatment against cervical cancer.
Kaila P. Medina-Alarcón,Aline Raquel Voltan,Bruno Fonseca-Santos,Isabela Jacob Moro,Felipe de Oliveira Souza,Marlus Chorilli,Christiane Pienna Soares,André Gonzaga dos Santos,Maria José Soares Mendes-Giannini,Ana Marisa Fusco-Almeida +9 more
TL;DR: This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles), liposomes, nanoemulsions and polymeric nanoparticles, and the main advantages of drug delivery thus improving pharmacological activity, improving solubility, bioavailability to bioavailability reducing toxicity in the target tissue by targeting of ligands.
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