Journal ArticleDOI
Bis-phosphonium salts of pyridoxine: The relationship between structure and antibacterial activity
Mikhail V. Pugachev,Nikita V. Shtyrlin,Sergey V. Sapozhnikov,L. P. Sysoeva,Alfiya G. Iksanova,Elena V. Nikitina,Rashid Z. Musin,Olga A. Lodochnikova,Eugeny A. Berdnikov,Yurii G. Shtyrlin +9 more
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TLDR
In practically all cases chemical modifications of compound 1 led to the increase of its toxicity for HEK-293 cells, the only exception is compound 5,6-bis[tributylphosphonio(methyl)]-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine dichloride (10a), which demonstrated lower MIC values against S. aureus and S. epidermidAbout:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2013-12-01. It has received 30 citations till now. The article focuses on the topics: Antibacterial activity & Pyridoxine.read more
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New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius
Zhi-Qiang Bai,Xiuping Lin,Yizhu Wang,Junfeng Wang,Xuefeng Zhou,Bin Yang,Juan Liu,Xian-Wen Yang,Yi Wang,Yonghong Liu +9 more
TL;DR: Two new aromatic butyrolactones, flavipesins A and B, two new natural products, and a known phenyl dioxolanone were isolated from marine-derived endophytic fungus Aspergillus flavipes.
Journal ArticleDOI
New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells.
Airat R. Kayumov,Aliya A. Nureeva,Elena Y. Trizna,G. R. Gazizova,Mikhail I. Bogachev,Nikita V. Shtyrlin,Mikhail V. Pugachev,Sergey V. Sapozhnikov,Yurii G. Shtyrlin +8 more
TL;DR: The antibacterial activity of newly synthesized cationic biocides, the quaternary ammonium, and bisphosphonium salts of pyridoxine are shown against biofilm-embedded Staphylococcus aureus and S. epidermidis to suggest that new synthetic antibiotics and disinfectants for external application againstBiofilm- embedded cells are suggested.
Journal ArticleDOI
New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
Zhi-Qiang Bai,Xiuping Lin,Junfeng Wang,Xuefeng Zhou,Juan Liu,Bin Yang,Xian-Wen Yang,Shengrong Liao,Lishu Wang,Yonghong Liu +9 more
TL;DR: Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes, and a possible biogenetic pathway of compounds 1–7 was proposed.
Journal ArticleDOI
Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?
Elena V. Nikitina,Marina I. Zeldi,Mikhail V. Pugachev,Sergey V. Sapozhnikov,Nikita V. Shtyrlin,Svetlana V. Kuznetsova,Vladimir E. Evtygin,Mikhail I. Bogachev,Airat R. Kayumov,Yurii G. Shtyrlin +9 more
TL;DR: Both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria and Escherichia coli considerably, while demonstrated nearly no effect against Klebsiella pneumoniae and Pseudomonas aeruginosa.
Journal ArticleDOI
Chemistry of pyridoxine in drug design
Yurii G. Shtyrlin,A. S. Petukhov,A. D. Strel’nik,Nikita V. Shtyrlin,Alfiya G. Iksanova,Mikhail V. Pugachev,Roman S. Pavelyev,Mikhail S. Dzyurkevich,Marsel R. Garipov,Konstantin V. Balakin +9 more
TL;DR: Methods for their synthesis, key pharmacological properties, and medicinal chemistry concepts underlying the design of the developing physiologically active pyridoxine derivatives are presented.
References
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A short history of SHELX
TL;DR: This paper could serve as a general literature citation when one or more of the open-source SH ELX programs (and the Bruker AXS version SHELXTL) are employed in the course of a crystal-structure determination.
Journal ArticleDOI
Revised methods for the salmonella mutagenicity test
Dorothy M. Maron,Bruce N. Ames +1 more
TL;DR: Two new tester strains, a frameshift strain and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set and two substitutions are made in diagnostic mutagens to eliminate MNNG and 9-aminoacridine.
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Clinical Relevance of Bacteriostatic versus Bactericidal Mechanisms of Action in the Treatment of Gram-Positive Bacterial Infections
G. A. Pankey,Leon D. Sabath +1 more
TL;DR: Although bacteriostatic/bactericidal data may provide valuable information on the potential action of antibacterial agents in vitro, it is necessary to combine this information with pharmacokinetic and pharmacodynamic data to provide more meaningful prediction of efficacy in vivo.
Journal ArticleDOI
The emergence and evolution of methicillin-resistant Staphylococcus aureus.
TL;DR: Recent epidemiological data imply that MRSA has embarked on another evolutionary path as a community pathogen, as at least one novel SCCmec element seems to have been successful in converting S. aureus strains from the normal human flora into MRSA.
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The evolution of Staphylococcus aureus.
TL;DR: The latest observations about the structure of SCCmec are described, the techniques used to study the molecular epidemiology and evolution of S. aureus as well as some challenges that researchers face in the future are described.