Journal ArticleDOI
Bonelike apatite growth on hydroxyapatite–gelatin sponges from simulated body fluid
TLDR
In vitro bioactivity of gelatin sponges and hydroxyapatite-enriched gelatinSponges was tested through evaluation of the variations in their composition and morphology after soaking in simulated body fluid for periods up to 21 days at 37 degrees C.Abstract:
In vitro bioactivity of gelatin sponges and hydroxyapatite-enriched gelatin sponges was tested through evaluation of the variations in their composition and morphology after soaking in simulated body fluid (1.5) for periods up to 21 days at 37°C. The presence of hydroxyapatite inside the sponges promotes the deposition of bonelike apatite crystals. The deposits are laid down as spherical aggregates, with mean diameters increasing from about 1–2 μm, after 4 days of soaking in simulated body fluid solution, up to about 3.5 μm in the samples soaked for 21 days. Simultaneously, the relative amount of inorganic phase increases up to about 56% wt, leading to a composite material with a composition quite close to that of bone tissue. The inorganic phase is a poor crystalline carbonated apatite similar to trabecular bone apatite. © 2001 Wiley Periodicals, Inc. J Biomed Mater Res 59: 709–714, 2002read more
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Polymeric scaffolds in tissue engineering application: a review
TL;DR: An overview of the different types of scaffolds with their material properties is discussed and the fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.
Journal ArticleDOI
Indirect Solid Free Form Fabrication of Local and Global Porous, Biomimetic and Composite 3D Polymer-Ceramic Scaffolds
TL;DR: In this article, solid free form (SFF) manufacturing with conventional sponge scaffold fabrication procedures was used for casting scaffolds that contain designed and controlled locally porous and globally porous internal architectures.
Journal ArticleDOI
Coating electrospun poly(ε-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering
TL;DR: Results indicated that the hybrid system containing poly(epsilon-caprolactone), gelatin, and calcium phosphate could serve as a new class of biomimetic scaffolds for bone tissue engineering.
Journal ArticleDOI
Current Concepts in Scaffolding for Bone Tissue Engineering.
Toktam Ghassemi,Azadeh Shahroodi,Mohammad H Ebrahimzadeh,Alireza Mousavian,Jebraeel Movaffagh,Ali Moradi +5 more
TL;DR: This paper reviews studies on bone tissue engineering from the biomaterial point of view in scaffolding and concludes that physiochemical modifications in terms of porosity, mechanical strength, cell adhesion, biocompatibility, cell proliferation, mineralization and osteogenic differentiation are required.
Journal ArticleDOI
Functional biopolymer nanocomposites based on layered solids
TL;DR: Bio-nanocomposites are an emerging group of hybrid materials derived from natural polymers and inorganic solids interacting at the nanometric scale as mentioned in this paper, which could be designed and prepared using a wide type of biopolymers and also in organic solids with different compositions and topologies.
References
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Journal ArticleDOI
Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants
TL;DR: A review of the past, present, and future of the hydroxyapatite (HAp)-based biomaterials from the point of view of preparation of hard tissue replacement implants is presented in this paper.
Journal ArticleDOI
Biomaterial developments for bone tissue engineering
TL;DR: The clinical need for bone tissue-engineered alternatives to the present materials used in bone grafting techniques is presented, a status report on clinically availableBone tissue-engineering devices, and recent advances in biomaterials research are presented.
Journal ArticleDOI
Osteonectin, A Bone-Specific Protein Linking Mineral to Collagen
John D. Termine,Hynda K. Kleinman,S. William Whitson,Kathleen M. Conn,Mary L. McGarvey,George R. Martin +5 more
TL;DR: It is suggested that osteonectin is a tissue-specific protein, linking the bone mineral and collagen phases, perhaps initiating active mineralization in normal skeletal tissue.
Journal ArticleDOI
Ca, P‐rich layer formed on high‐strength bioactive glass‐ceramic A‐W
Tadashi Kokubo,Setsuro Ito,Z. T. Huang,Takeshi Hayashi,Sumio Sakka,Toshiaki Kitsugi,Takao Yamamuro +6 more
TL;DR: It is concluded that the essential condition for glass and glass-ceramic to bond to bone is the formation of the surface apatite layer in the body environment but it is not essential to contain apatites within the material.
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Biomaterials: a forecast for the future
TL;DR: It is proposed that biomaterials research needs to focus on regeneration of tissues instead of replacement, and hierarchical bioactive scaffolds to engineer in vitro living cellular constructs for transplantation, or use resorbable bioactive particulates or porous networks to activate the mechanisms of tissue regeneration.
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