Journal ArticleDOI
Ca2+-induced Ca2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes
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TLDR
In this paper, the authors investigated the effects and mechanisms of calcitonin gene-related peptide (CGRP) on ventricular contractility, ventricular myocytes isolated from adult rat and mouse hearts were exposed to CGRP.Abstract:
To investigate the effects and mechanisms of calcitonin gene-related peptide (CGRP) on ventricular contractility, ventricular myocytes isolated from adult rat and mouse hearts were exposed to CGRP....read more
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Thyroid hormone and the cardiovascular system.
Irwin Klein,Kaie Ojamaa +1 more
TL;DR: Changes in serum T( 3) levels in patients with chronic congestive heart failure are caused by alterations in thyroid hormone metabolism suggesting that patients may benefit from T(3) replacement in this setting.
Journal ArticleDOI
Positive inotropic and lusitropic effects of HNO/NO− in failing hearts: Independence from β-adrenergic signaling
Nazareno Paolocci,Tatsuo Katori,Hunter C. Champion,Marcus E. St. John,Katrina M. Miranda,Jon M. Fukuto,David A. Wink,David A. Kass +7 more
TL;DR: HNO/NO− has positive inotropic and lusitropic action, which unlike NO/nitrates is independent and additive to β-adrenergic stimulation and stimulates CGRP release, which suggests potential of HNO/ NO− donors for the treatment of heart failure.
Journal ArticleDOI
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.
Nazareno Paolocci,Walter F. Saavedra,Katrina M. Miranda,Cristian Martignani,Takayoshi Isoda,Joshua M. Hare,Michael Graham Espey,Jon M. Fukuto,Martin Feelisch,David A. Wink,David A. Kass +10 more
TL;DR: No− is a redox-sensitive positive inotrope with selective venodilator action, whose cardiac effects are mediated by CGRP-receptor stimulation, and may prove useful for the treatment of cardiovascular diseases characterized by cardiac depression and elevated venous filling pressures.
Journal ArticleDOI
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
Katrina M. Miranda,Nazareno Paolocci,Tatsuo Katori,Douglas D. Thomas,Eleonora Ford,Michael D. Bartberger,Michael Graham Espey,David A. Kass,Martin Feelisch,Jon M. Fukuto,David A. Wink +10 more
TL;DR: The results suggest the existence of two mutually exclusive response pathways that involve stimulated release of discrete signaling agents from HNO and NO and that the lifetime of HNO with respect to oxidation to NO, dimerization, or reaction with O2 is much longer than previously assumed.
Journal ArticleDOI
The Pharmacology of Nitroxyl (HNO) and Its Therapeutic Potential: Not Just the Janus Face of NO
Nazareno Paolocci,Matthew I. Jackson,Brenda E. Lopez,Katrina M. Miranda,Carlo G. Tocchetti,David A. Wink,Adrian J. Hobbs,Jon M. Fukuto +7 more
TL;DR: In this review, a brief description of the biologically relevant chemistry of HNO is given, followed by a more detailed discussion of the pharmacology and potential toxicology of H NO.
References
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Regulation of cardiac l-type calcium current by
TL;DR: In this paper, a hypothetical scheme for the adrenergic control of Ca2+ cells by cAMP-dependent phosphorylation was proposed, but direct experimental evidence for this was still missing.
Journal ArticleDOI
A cDNA encoding the calcitonin gene-related peptide type 1 receptor.
Nambi Aiyar,Kinneret Rand,Nabil Elshourbagy,Zhizhen Zeng,John E. Adamou,Derk J. Bergsma,Yi Li +6 more
TL;DR: The cloning of a complementary DNA (cDNA) encoding a human CGRP receptor, which shares significant peptide sequence homology with the human calcitonin receptor, a member of the G-protein-coupled receptor superfamily, is reported here.
Journal ArticleDOI
Regulation of cardiac L-type calcium current by phosphorylation and G proteins.
W Trautwein,J Hescheler +1 more
TL;DR: Voltage-dependent Ca2+ channels play a major role in the electromechanical coupling of cardiac cells and are involved in the spontaneous impulse generation as well as in the duration of the action potentials and hence in refractoriness.
Journal ArticleDOI
Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects
TL;DR: CGRP turned out to be a strong vasodilator in vitro as tested on several blood vessels and potentially, perivascular CGRP/SP fibers have a dual role as regulator of local blood flow and as carrier of sensory information.
Journal Article
Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity.
TL;DR: The ligand selectivity profile observed in this study suggests that [125I] hCGRP binding sites present in rat brain and spleen are similar and it appears that it is possible to differentiate between CGRP receptor subtypes on the basis of differential agonistic and antagonistic potencies in various isolated tissues.