Journal ArticleDOI
Camptocormia in Parkinson disease: an epidemiological and clinical study
Dorina Tiple,Giovanni Fabbrini,Carlo Colosimo,Donatella Ottaviani,Filippo Camerota,Giovanni Defazio,Alfredo Berardelli +6 more
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TLDR
Camptocormia, a relatively common sign in Parkinson disease, seems to be related to the clinical severity of PD.Abstract:
Background: Camptocormia is an abnormal flexion of the thoracolumbar spine during standing and walking that abates in the recumbent position. Methods: In a single-centre epidemiological and clinical study, the prevalence of camptocormia in Parkinson disease (PD) and its relationship with the clinical features of PD were investigated. A total of 275 consecutive outpatients were systematically screened for camptocormia with a clinical evaluation. Patients who screened positive for camptocormia were subsequently reassessed by formal goniometric analysis. The demographic and clinical features of the patients with and without camptocormia were then compared. Results: A 6.9% (19/275, 95% CI, 4.2 to 10.6) prevalence of camptocormia was found. Camptocormia was found in patients with more severe PD, as clinically assessed by the Hoehn–Yahr (HY) staging and the motor Unified Parkinson Disease Rating Scale (UPDRS) part III, longer l-dopa treatment duration and greater l-dopa daily dose and presence of DSM-IV dementia. Camptocormia was reported to develop after the clinical onset of PD. No correlation was found between the degree of trunk flexion and age, duration of PD, UPDRS motor score, HY staging, and l-dopa treatment duration and dose. As a risk factor, the study identified previous vertebral surgery. Conclusions: Camptocormia, a relatively common sign in PD seems to be related to the clinical severity of PD.read more
Citations
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Journal ArticleDOI
An Essay on the Shaking Palsy
TL;DR: In this paper, the authors present a conciliatory explanation for the present publication, in which, it is acknowledged, that mere conjecture takes the place of experiment; and, that analogy is the substitute for anatomical examination, the only sure foundation for pathological knowledge.
Journal ArticleDOI
Postural deformities in Parkinson's disease
Karen M. Doherty,Bart P.C. van de Warrenburg,Maria Cecilia Peralta,Laura Silveira-Moriyama,Jean-Philippe Azulay,Oscar S. Gershanik,Bastiaan R. Bloem +6 more
TL;DR: Improved understanding of the mechanisms underlying postural deformities in PD might ultimately lead to more effective management strategies for these disabling and drug-refractory complications.
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Pathophysiology of NASH: perspectives for a targeted treatment.
Fabio Marra,Sophie Lotersztajn +1 more
TL;DR: The major mechanisms leading to appearance and progression of NASH are reviewed, focusing on both extrahepatic signals and local inflammatory mechanisms, in an effort to identify the most promising molecular targets for the treatment of this condition.
Journal ArticleDOI
Camptocormia in Parkinson's Disease
TL;DR: It is indicated that camptocormia is a relatively common sign in PD and that patients with camptoormia scores on the PDQ-8 compared with PD patients without camptOCormia suggests that improvements in camptokormia of PD patients may improve their QOL.
Journal ArticleDOI
Presentation, etiology, diagnosis, and management of camptocormia.
Josef Finsterer,Walter Strobl +1 more
TL;DR: Camptocormia (bent spine syndrome, cyphose hystérique) is an abnormality characterized by severe forward flexion of the thoracolumbar spine which typically increases during walking or standing and completely disappears in supine position.
References
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Journal ArticleDOI
Camptocormia in Parkinson's Disease
TL;DR: It is indicated that camptocormia is a relatively common sign in PD and that patients with camptoormia scores on the PDQ-8 compared with PD patients without camptOCormia suggests that improvements in camptokormia of PD patients may improve their QOL.
Journal Article
A specific clinical pattern of camptocormia in Parkinson's disease. Commentary
R. Djaldetti,E. Melamed,A.-C. Lepoutre,David Devos,A. Blanchard-Dauphin,V. Pardessus,Claude-Alain Maurage,D. Ferriby,J.-F. Hurtevent,A. Gotten,Alain Destée,Luc Defebvre +11 more
TL;DR: The screening and early management of camptocormia in Parkinson’s disease is likely to be important for preventing axial disorders and spinal deformations.
Book ChapterDOI
Epidemiology of Parkinson's disease.
TL;DR: The epidemiology of Parkinson's disease has been extensively studied in the literature as discussed by the authors, with a focus on the distribution of PD patients in the US population and the cause of the disease.
Journal ArticleDOI
Camptocormia in Parkinson's disease.
Eldad Melamed,Ruth Djaldetti +1 more
TL;DR: In a few patients, the abnormal posture improved and in others it was unaltered or even became worse following levodopa administration, but in most, the severity of camptocormia was unchanged during the “on” and “off” phases.
Journal ArticleDOI
Camptocormia, axial dystonia, and parkinsonism: Phenotypic heterogeneity of a parkin mutation
Rivka Inzelberg,Nobutaka Hattori,P. Nisipeanu,S. Abo Mouch,Sergiu C. Blumen,R.L. Carasso,Yoshikuni Mizuno +6 more
TL;DR: A large kindred with different phenotypic expressions of a mutation in the parkin gene is described, with patients belonging to two branches of an Arabic Israeli family with young-onset parkinsonism.
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