Journal ArticleDOI
Canine Leishmania vaccines: still a long way to go.
TLDR
Only two vaccines showed to confer significant protection against disease and death under natural conditions, and have been registered as canine vaccines: FML-QuilA (Leishmune(®) in Brazil, and LiESP/QA-21 (CaniLeish(®)) in Europe.About:
This article is published in Veterinary Parasitology.The article was published on 2015-02-28. It has received 91 citations till now. The article focuses on the topics: Leishmania infantum & Leishmaniasis Vaccines.read more
Citations
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Journal ArticleDOI
Recent updates and perspectives on leishmaniasis
TL;DR: The diagnostic, chemotherapeutic, and immunizing strategies to control leishmaniasis are highlighted, though no human vaccine is commercially available currently owing to the complexity of the cellular immune response to this parasite.
Journal ArticleDOI
Vaccines for visceral leishmaniasis: A review.
Keerti Jain,N. K. Jain +1 more
TL;DR: Visceral leishmaniasis is one of the most severely neglected tropical diseases recognized by the World Health Organization and few vaccines including Leishmune®, Leishtec, and CaniLeish® have been licensed for canine visceral leish maniasis.
Journal ArticleDOI
Best Practices for Preventing Vector-Borne Diseases in Dogs and Humans
TL;DR: The control of these diseases would ultimately improve animal and human health and wellbeing, particularly in developing countries in the tropics, where the risk ofThese diseases is high and access to health care is poor.
Journal ArticleDOI
Leishmania vaccines entered in clinical trials: A review of literature
TL;DR: Recently, ChAd63-KH DNA vaccine has been accomplished in providing prevention against Leishmania infection; however, this vaccine should be further evaluated in other clinical trials.
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Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance
TL;DR: The ability of Leishmania to respond to drug pressure by CNVs has led to the development of genomic screens such as Cos-Seq, which has the potential of expediting the discovery of drug targets for novel promising drug candidates.
References
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Journal ArticleDOI
Leishmaniasis Worldwide and Global Estimates of Its Incidence
Jorge Alvar,Iván D. Vélez,Iván D. Vélez,Caryn Bern,Mercè Herrero,Philippe Desjeux,Jorge Cano,Jean Jannin,Margriet den Boer +8 more
TL;DR: Visceral and cutaneous leishmaniasis incidence ranges were estimated by country and epidemiological region based on reported incidence, underreporting rates if available, and the judgment of national and international experts.
Journal ArticleDOI
Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one.
TL;DR: An updated view on progress in elucidating the epidemiology and pathogenesis of canine leishmaniosis is presented, and the second part focuses on advances in diagnosis, treatment and prevention.
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Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis
Laia Solano-Gallego,A. F. Koutinas (Α.Φ. Κουτινασ),Guadalupe Miró,Luís Cardoso,Maria Grazia Pennisi,Lluís Ferrer,Patrick Bourdeau,Gaetano Oliva,Gad Baneth +8 more
TL;DR: A consensus of opinions on the diagnosis, treatment, prognosis and prevention of CanL is presented, and a system of four clinical stages, based on clinical signs, clinicopathological abnormalities and serological status is proposed.
Journal Article
The control of leishmaniases
TL;DR: Control of zoonotic cutaneous/mucocutaneous leishmaniasis of the New World is hardly feasible at present, and the only rational approach to prevent some of mucosal lesions is early diagnosis and radical treatment of patients with the rather unsatisfactory drugs at present available.
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The current status of zoonotic leishmaniases and approaches to disease control.
Marina Gramiccia,Luigi Gradoni +1 more
TL;DR: A number of tools have been developed for the control of the canine reservoir of L. infantum, including several canine vaccine candidates, in particular an FML Leishmania enriched fraction showing good clinical protection, and a number of insecticide-based preparations for dog protection against sand fly bites.