Journal ArticleDOI
Cascade Rearrangements Following Twofold Addition of Alkenyl Anions to Squarate Esters
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TLDR
The double 1,2-addition of alkenyl, cycloalkenyl, and alkynyllithium reagents to squarate esters constitutes a very expedient method for rapidly increasing structural complexity with formation of polycyclic end products.About:
This article is published in European Journal of Organic Chemistry.The article was published on 1998-09-01. It has received 34 citations till now. The article focuses on the topics: Chirality (chemistry).read more
Citations
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Journal ArticleDOI
Cascade reactions in total synthesis.
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
Journal ArticleDOI
Natural product synthesis using multicomponent reaction strategies.
B. Barry Touré,Dennis G. Hall +1 more
TL;DR: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis, a task deemed inconceivable by early practitioners.
Journal ArticleDOI
The application of cyclobutane derivatives in organic synthesis.
TL;DR: Transformation of Cyclobutane Derivatives inNatural Product Syntheses: A Review of the Transformations in Organic Syntheses.
Journal ArticleDOI
Kaskadenreaktionen in der Totalsynthese
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,David J. Edmonds,David J. Edmonds,Paul G. Bulger,Paul G. Bulger +5 more
TL;DR: In this article, ausgewahlte Kaskadenreaktionen in der Naturstoffsynthese erlautert, wobei neuere Anwendungen besonders hervorgehoben werden.
Journal ArticleDOI
Beyond the Divinyl Ketone: Innovations in the Generation and Nazarov Cyclization of Pentadienyl Cation Intermediates.
TL;DR: Methods reviewed include carbon-heteroatom ionization, functionalization of a double bond, nucleophilic addition, or electrocyclic ring opening for generating the pentadienyl cation intermediate central to the Nazarov cyclization.
References
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Journal ArticleDOI
Electronic Control of Stereoselectivities of Electrocyclic Reactions of Cyclobutenes: A Triumph of Theory in the Prediction of Organic Reactions
TL;DR: In this article, it was shown that cyclobutene can be converted to butadiene at 150 °C, a relatively low temperature compared to the 350 °C required for thermal cleavage of the almost equally strained cyclomethane.
Journal ArticleDOI
Stereoselective substituent effects on conrotatory electrocyclic reactions of cyclobutenes
Journal ArticleDOI
Theory of stereoselection in conrotatory electrocyclic reactions of substituted cyclobutenes
Nelson G. Rondan,Kendall N. Houk +1 more
Related Papers (5)
Applications of the squarate ester cascade to the expeditious synthesis of hypnophilin, coriolin, and ceratopicanol.
Leo A. Paquette,Feng Geng +1 more