Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors.
Ponnal Nambi,David R. Sibley,Jeffrey M. Stadel,Thomas Michel,Jack R. Peters,Robert J. Lefkowitz +5 more
TLDR
Data indicate that beta-adrenergic agonists promote a cAMP-mediated process which leads to receptor alterations and desensitization, and the availability of this cell-free system should facilitate elucidation of the molecular mechanisms involved in these processes.About:
This article is published in Journal of Biological Chemistry.The article was published on 1984-04-10 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Homologous desensitization & Desensitization (medicine).read more
Citations
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Journal ArticleDOI
Molecular mechanisms of receptor desensitization using the β -adrenergic receptor-coupled adenylate cyclase system as a model
TL;DR: New insights into the molecular mechanisms underlying desensitization have emerged from the study of the receptors coupled to the ubiquitous second messenger-generating system adenylate cyclase.
Journal ArticleDOI
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
TL;DR: The existence of this novel cAMP-independent kinase, which preferentially phosphorylates the agonist-occupied form of the beta-adrenergic receptor, suggests a mechanism that may explain the homologous or agonists-specific form of adenylate cyclase desensitization and suggests a general mechanism for regulation of receptor function.
Journal ArticleDOI
Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes
David R. Sibley,David R. Sibley,Ponnal Nambi,Ponnal Nambi,Jack R. Peters,Jack R. Peters,Robert J. Lefkowiz,Robert J. Lefkowiz +7 more
TL;DR: A potential role for protein kinase C in regulating beta-adrenergic receptor function is suggested in regulatingalpha-phorbol diesters or catecholamines and in promoting adenylate cyclase desensitization in duck erythrocytes with tumor promotion.
Journal ArticleDOI
Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.
TL;DR: Observations suggest that "feedback" and "cross-system" phosphorylation may represent distinct and differently regulated mechanisms of modulation of receptor function.
Journal ArticleDOI
Neuronal phosphoproteins: physiological and clinical implications
TL;DR: The presence of a great variety of neuron-specific phosphoproteins in nervous tissue supports the view that protein phosphorylation plays many roles in neuronal function.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.
Journal ArticleDOI
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites
TL;DR: Data suggest that beta-adrenergic catecholamines are able to regulate catechlamine sensitivity of tissues in vivo, by regulating the properties of the beta- adrenergic receptor binding sites.
Related Papers (5)
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.
Y F Su,T K Harden,J P Perkins +2 more