Journal ArticleDOI
Cellular Basis for the Electrocardiographic J Wave
Gan-Xin Yan,Charles Antzelevitch +1 more
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TLDR
The results provide the first direct evidence in support of the hypothesis that heterogeneous distribution of a transient outward current-mediated spike-and-dome morphology of the action potential across the ventricular wall underlies the manifestation of the electrocardiographic J wave.Abstract:
Background The J wave is a deflection that appears in the ECG as a late delta wave following the QRS or as a small secondary R wave (R′). Also referred to as an Osborn wave, the J wave has been observed in the ECG of animals and humans for more than four decades, yet the mechanism underlying its manifestation is poorly understood. The present study investigates the cellular basis for the J wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle. Methods and Results A 12-lead ECG was initially recorded in vivo. After isolation and arterial perfusion of the right or left ventricular wedge, transmembrane action potentials were simultaneously recorded from epicardial, M region, and endocardial transmural sites with three floating microelectrodes. A transmural ECG was recorded concurrently. A J wave was observed at the R-ST junction of the ECG in 17 of 20 adult dogs, usually in leads II, III, aVR, and aVF and the mid to lateral precordial leads. The J wave...read more
Citations
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Journal ArticleDOI
Effect of short-term cardiac memory on ventricular electrical restitution and QT intervals in humans.
Kun-Tai Lee,Chih-Sheng Chu,Kai-Hung Cheng,Ye-Hsu Lu,Chih-Hsin Huang,Tsung-Hsien Lin,Ming-Chuan Lee,Sheng-Hsiung Sheu,Wen-Ter Lai +8 more
TL;DR: It is suggested that CM might not have a significant effect on ventricular arrhythmogenicity and the maximal slope of the action potential duration restitution curve (APDR) constructed by programmed extra stimuli from RVA is not changed.
Journal ArticleDOI
Clinical significance of J waves with respect to substrate characteristics and ablation outcomes in patients with arrhythmogenic right ventricular cardiomyopathy.
Chin Yu Lin,Fa Po Chung,Yenn Jiang Lin,Shih Lin Chang,Li Wei Lo,Yu Feng Hu,Ta Chuan Tuan,Tze Fan Chao,Jo Nan Liao,Ting Yung Chang,Ling Kuo,Cheng I. Wu,Chih Min Liu,Shin Huei Liu,Wen Han Cheng,Isaiah C. Lugtu,Abigail Louise D. Te,Ting Chun Huang,Po Tseng Lee,Jennifer Jeanne B. Vicera,Shih Ann Chen +20 more
TL;DR: In this paper, the authors investigated the significance of J-wave syndrome with respect to substrate manifestations and ablation outcomes in patients with arrhythmogenic right ventricular cardiomyopathy.
Journal ArticleDOI
Autodetection of J Wave Based on Random Forest with Synchrosqueezed Wavelet Transform.
TL;DR: A new method to realize the automatic detection of J wave is proposed, which has achieved the highest accuracy, sensitivity, and specificity compared with existing techniques.
Journal ArticleDOI
A new point on ECG: point L as identifier of rapid and slow ejection phases boundary
TL;DR: The equations were employed to verify the balance of the phase-related diastolic and systolic blood volumes reliant on phase durations, and the identification of boundaries of the cardiac cycle phases on the ECG.
Book ChapterDOI
Genetics, Molecular Biology, and Emerging Concepts of Early Repolarization Syndrome
TL;DR: The most effective therapy for the prevention of SCD in high-risk ERS patients is an implantable cardioverter defibrillator (ICD), and the pharmacologic approach to therapy involves inhibition of Ito, augmentation of ICa or slowing of inactivation of INa.
References
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Journal ArticleDOI
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
TL;DR: Common clinical and ECG features define a distinct syndrome in this group of patients with recurrent episodes of aborted sudden death unexplainable by currently known diseases, not explainable by electrolyte disturbances, ischemia or structural heart disease.
Journal ArticleDOI
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Charles Antzelevitch,Serge Sicouri,Silvio H. Litovsky,Anton Lukas,S C Krishnan,J. M. Di Diego,G. A. Gintant,Da-Wei Liu +7 more
TL;DR: In spite of important advances in cardiology in recent years, pharmacological control of cardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient basis using a trial and error approach tempered by good clinical judgment.
Journal ArticleDOI
Inward current channels activated by intracellular Ca in cultured cardiac cells.
TL;DR: Researchers report here studies on single channel currents recorded from heart muscle cells, in which they have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories.
Journal ArticleDOI
Characteristics of the Delayed Rectifier Current (IKr and IKs) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes A Weaker IKs Contributes to the Longer Action Potential of the M Cell
Da-Wei Liu,Charles Antzelevitch +1 more
TL;DR: The results suggest that the distinctive phase-3 repolarization features of M cells are due in part to a lesser contribution of IKs and that this distinction may also explain why M Cells are the main targets for agents that prolong APD in ventricular myocardium.
Journal ArticleDOI
Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts.
TL;DR: It is proposed that the parallel orientation of the muscle bundles in the epicardial border zone is an important cause of ventricular tachycardia because activation transverse to myocardial fibers is sufficiently slow to permit the occurrence of reentry.
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