Journal ArticleDOI
Inward current channels activated by intracellular Ca in cultured cardiac cells.
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TLDR
Researchers report here studies on single channel currents recorded from heart muscle cells, in which they have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories.Abstract:
Present concepts of excitable membrane function are based primarily on knowledge of two classes of channels: those activated by neurotransmitters1 and those activated by membrane potential2. Recent evidence suggests that these notions may have to be modified to include other channel types, such as special ion channels activated by membrane potential but regulated by ligands3–5. We report here studies on single channel currents recorded from heart muscle cells, in which we have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories. This channel shows little selectivity between cations, but excludes anions. It is activated by intracellular Ca ions but is not appreciably affected by membrane potential.read more
Citations
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Journal ArticleDOI
Multiple calcium channels and neuronal function
TL;DR: It is shown that neurons have a number of different types of calcium channels, each with their own unique properties and pharmacology, and these calcium channels may be important in the control of different aspects of nerve activity.
Journal ArticleDOI
Calcium channel modulation by neurotransmitters, enzymes and drugs
TL;DR: Calcium channels in excitable membranes are of great importance for many cellular functions and modulation by neurotransmitters and drugs regulates calcium influx into the cell and thereby alters the functional state of the cell.
Journal ArticleDOI
Calcium cycling and signaling in cardiac myocytes.
TL;DR: This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophysiology, excitation-contraction coupling, modulation of contractile function, energy supply-demand balance, cell death, and transcription regulation.
Journal ArticleDOI
Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.
Bo K. Siesjö,Finn Bengtsson +1 more
TL;DR: The hypothesis predicts that loss of cellular calcium ho meostasis underlies selective neuronal vulnerability in ischemia, hypoglycemia, and epileptic seizures and that some cells are more vulner able than others because they have a higher density of calcium channels in their plasma membranes.
Journal ArticleDOI
Sodium and calcium channels in bovine chromaffin cells
TL;DR: Inward currents in chromaffin cells were studied with the patch‐clamp technique and current recordings were obtained in cell‐attached, outside‐out and whole‐cell recording configurations.
References
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Journal ArticleDOI
A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
Journal ArticleDOI
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
TL;DR: The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches.
Journal ArticleDOI
Muscarinic suppression of a novel voltage-sensitive K + current in a vertebrate neurone
D.A. Brown,D.A. Brown,Paul Adams +2 more
TL;DR: Using voltage-clamped frog sympathetic neurones, this work has identified a distinctive voltage-sensitive K+ -current, separate from the delayed rectifier current, as the prime target for muscarinic agonists, and termed this current the M-current, IM.