Journal ArticleDOI
Cellular Basis for the Electrocardiographic J Wave
Gan-Xin Yan,Charles Antzelevitch +1 more
Reads0
Chats0
TLDR
The results provide the first direct evidence in support of the hypothesis that heterogeneous distribution of a transient outward current-mediated spike-and-dome morphology of the action potential across the ventricular wall underlies the manifestation of the electrocardiographic J wave.Abstract:
Background The J wave is a deflection that appears in the ECG as a late delta wave following the QRS or as a small secondary R wave (R′). Also referred to as an Osborn wave, the J wave has been observed in the ECG of animals and humans for more than four decades, yet the mechanism underlying its manifestation is poorly understood. The present study investigates the cellular basis for the J wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle. Methods and Results A 12-lead ECG was initially recorded in vivo. After isolation and arterial perfusion of the right or left ventricular wedge, transmembrane action potentials were simultaneously recorded from epicardial, M region, and endocardial transmural sites with three floating microelectrodes. A transmural ECG was recorded concurrently. A J wave was observed at the R-ST junction of the ECG in 17 of 20 adult dogs, usually in leads II, III, aVR, and aVF and the mid to lateral precordial leads. The J wave...read more
Citations
More filters
Journal ArticleDOI
Transient and rapid QRS-widening associated with a J-wave pattern predicts impending ventricular fibrillation in experimental myocardial infarction
Marina M. Demidova,Alba Martin-Yebra,Alba Martin-Yebra,Jesper van der Pals,Sasha Koul,David Erlinge,Pablo Laguna,Juan Pablo Martinez,Pyotr G. Platonov +8 more
TL;DR: Transient QRS widening, commonly associated with a J-wave pattern, appears to predict impending VF in acute ischemia settings and motivates further clinical studies for monitoring immediate risk of VF with myocardial infarction in MI.
Journal ArticleDOI
Experimental Models of Brugada syndrome.
Franziska Sendfeld,Elisabet Selga,Fabiana S. Scornik,Guillermo J. Pérez,Nicholas L. Mills,Ramon Brugada +5 more
TL;DR: An evaluation of the strengths and limitations of each of these model systems is provided and a summary of the key mechanisms that have been identified to date are summarized.
Journal ArticleDOI
Phase 2 reentry in man
Poul Erik Bloch Thomsen,Rikke Moerch Joergensen,Jørgen K. Kanters,Thomas Jensen,Jens Haarbo,Arne Hagemann,Annette Vestergaard,Knud Særmark +7 more
TL;DR: J-point elevation, ST-elevation, and T-wave changes documented in the last sinus beat prior to ventricular extrasystoles are in agreement with phase 2 reentry, suggesting that this may be the responsible mechanism for ventricular extensions and ventricular tachycardia/fibrillation.
Book ChapterDOI
Cardiac Arrhythmias Related to Sodium Channel Dysfunction.
TL;DR: The goal in this chapter is to review and discuss what is known about the clinical phenotype and genotype of each cardiac sodium channelopathy, and to briefly discuss the underlying mechanisms.
Journal ArticleDOI
Electrocardiographic J waves as a hyperacute sign of Takotsubo syndrome.
Alessandro Zorzi,Federico Migliore,Martina Perazzolo Marra,Giuseppe Tarantini,Sabino Iliceto,Domenico Corrado +5 more
TL;DR: The case report shows that recording of ECG J waves in postmenopausal women presenting for acute chest pain may be a sign of an ongoing TTS and suggests a similarity to myocardial ischemia as the pathologic basis.
References
More filters
Journal ArticleDOI
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
TL;DR: Common clinical and ECG features define a distinct syndrome in this group of patients with recurrent episodes of aborted sudden death unexplainable by currently known diseases, not explainable by electrolyte disturbances, ischemia or structural heart disease.
Journal ArticleDOI
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Charles Antzelevitch,Serge Sicouri,Silvio H. Litovsky,Anton Lukas,S C Krishnan,J. M. Di Diego,G. A. Gintant,Da-Wei Liu +7 more
TL;DR: In spite of important advances in cardiology in recent years, pharmacological control of cardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient basis using a trial and error approach tempered by good clinical judgment.
Journal ArticleDOI
Inward current channels activated by intracellular Ca in cultured cardiac cells.
TL;DR: Researchers report here studies on single channel currents recorded from heart muscle cells, in which they have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories.
Journal ArticleDOI
Characteristics of the Delayed Rectifier Current (IKr and IKs) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes A Weaker IKs Contributes to the Longer Action Potential of the M Cell
Da-Wei Liu,Charles Antzelevitch +1 more
TL;DR: The results suggest that the distinctive phase-3 repolarization features of M cells are due in part to a lesser contribution of IKs and that this distinction may also explain why M Cells are the main targets for agents that prolong APD in ventricular myocardium.
Journal ArticleDOI
Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts.
TL;DR: It is proposed that the parallel orientation of the muscle bundles in the epicardial border zone is an important cause of ventricular tachycardia because activation transverse to myocardial fibers is sufficiently slow to permit the occurrence of reentry.
Related Papers (5)
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
Sudden Cardiac Arrest Associated with Early Repolarization
Michel Haïssaguerre,Nicolas Derval,Frederic Sacher,Laurence Jesel,Isabel Deisenhofer,Luc De Roy,Jean-Luc Pasquié,Akihiko Nogami,Dominique Babuty,Sinikka Yli-Mäyry,Christian de Chillou,Patrice Scanu,Philippe Mabo,Seiichiro Matsuo,Vincent Probst,Solena Le Scouarnec,Pascal Defaye,Juerg Schlaepfer,Thomas Rostock,Dominique Lacroix,Dominique Lamaison,Thomas Lavergne,Yoshifusa Aizawa,Anders Englund,Frédéric Anselme,Mark D O'Neill,Mélèze Hocini,Kang-Teng Lim,Sébastien Knecht,George D. Veenhuyzen,Pierre Bordachar,Michel Chauvin,Pierre Jaïs,Gaelle Coureau,Geneviève Chêne,George Klein,Jacques Clémenty +36 more
Cellular Basis for the Brugada Syndrome and Other Mechanisms of Arrhythmogenesis Associated With ST-Segment Elevation
Gan-Xin Yan,Charles Antzelevitch +1 more