Journal ArticleDOI
Cellular Basis for the Electrocardiographic J Wave
Gan-Xin Yan,Charles Antzelevitch +1 more
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TLDR
The results provide the first direct evidence in support of the hypothesis that heterogeneous distribution of a transient outward current-mediated spike-and-dome morphology of the action potential across the ventricular wall underlies the manifestation of the electrocardiographic J wave.Abstract:
Background The J wave is a deflection that appears in the ECG as a late delta wave following the QRS or as a small secondary R wave (R′). Also referred to as an Osborn wave, the J wave has been observed in the ECG of animals and humans for more than four decades, yet the mechanism underlying its manifestation is poorly understood. The present study investigates the cellular basis for the J wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle. Methods and Results A 12-lead ECG was initially recorded in vivo. After isolation and arterial perfusion of the right or left ventricular wedge, transmembrane action potentials were simultaneously recorded from epicardial, M region, and endocardial transmural sites with three floating microelectrodes. A transmural ECG was recorded concurrently. A J wave was observed at the R-ST junction of the ECG in 17 of 20 adult dogs, usually in leads II, III, aVR, and aVF and the mid to lateral precordial leads. The J wave...read more
Citations
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Journal ArticleDOI
Different rate-dependent responses between J waves and the notches on an epicardial local electrogram in a patient with idiopathic ventricular fibrillation
TL;DR: A case of an IVF patient, diagnosed as possible ERS by the proposed Shanghai ERS Score, in whom the rate-dependent change of the J waves was not evident on a standard ECG but was distinct in the notches in the local electrograms recorded from the epicardial surface of the left ventricle.
Book ChapterDOI
Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification
Nicolas Derval,Frederic Sacher,Ashok J. Shah,Sébastien Knecht,Mélèze Hocini,Pierre Jais,Michel Haïssaguerre +6 more
TL;DR: Clinical features as personal history of syncope, familial history of sudden cardiac death and characteristics of the J-wave should be considered at higher risk of early repolarization, especially for asymptomatic patient.
Journal ArticleDOI
Une tachycardie ventriculaire (TV) fasciculaire maligne dégénérant en fibrillation ventriculaire (FV) associée à un syndrome de repolarisation précoce
TL;DR: A 45-year-old man was hospitalized for syncope due to fascicular ventricular tachycardia degenerating into ventricular fibrillation (VF), and an implantable cardioverter-defibrillator was implanted; subsequently, the patient was arrhythmia free at 9 months follow-up.
Journal ArticleDOI
Ischaemia-induced J waves
TL;DR: This article comments on a recently published case of ischemia-induced J waves aiming to highlight the utility of these waves in localizing the culprit artery as well as in classifying the patient among those at high risk for malignant arrhythmias.
Journal ArticleDOI
Brugada Syndrome and Carbohydrate Metabolism
TL;DR: Brugada syndrome is recognized worldwide, although the prevalence seems much higher in some areas than in other areas, and in Asia the plenty of cases were reported from Japan, Thailand, Taiwan, China, India, Laos, Vietnam, Singapore and Cambodia.
References
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Journal ArticleDOI
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
TL;DR: Common clinical and ECG features define a distinct syndrome in this group of patients with recurrent episodes of aborted sudden death unexplainable by currently known diseases, not explainable by electrolyte disturbances, ischemia or structural heart disease.
Journal ArticleDOI
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Charles Antzelevitch,Serge Sicouri,Silvio H. Litovsky,Anton Lukas,S C Krishnan,J. M. Di Diego,G. A. Gintant,Da-Wei Liu +7 more
TL;DR: In spite of important advances in cardiology in recent years, pharmacological control of cardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient basis using a trial and error approach tempered by good clinical judgment.
Journal ArticleDOI
Inward current channels activated by intracellular Ca in cultured cardiac cells.
TL;DR: Researchers report here studies on single channel currents recorded from heart muscle cells, in which they have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories.
Journal ArticleDOI
Characteristics of the Delayed Rectifier Current (IKr and IKs) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes A Weaker IKs Contributes to the Longer Action Potential of the M Cell
Da-Wei Liu,Charles Antzelevitch +1 more
TL;DR: The results suggest that the distinctive phase-3 repolarization features of M cells are due in part to a lesser contribution of IKs and that this distinction may also explain why M Cells are the main targets for agents that prolong APD in ventricular myocardium.
Journal ArticleDOI
Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts.
TL;DR: It is proposed that the parallel orientation of the muscle bundles in the epicardial border zone is an important cause of ventricular tachycardia because activation transverse to myocardial fibers is sufficiently slow to permit the occurrence of reentry.
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