Journal ArticleDOI
Cellular Basis for the Electrocardiographic J Wave
Gan-Xin Yan,Charles Antzelevitch +1 more
Reads0
Chats0
TLDR
The results provide the first direct evidence in support of the hypothesis that heterogeneous distribution of a transient outward current-mediated spike-and-dome morphology of the action potential across the ventricular wall underlies the manifestation of the electrocardiographic J wave.Abstract:
Background The J wave is a deflection that appears in the ECG as a late delta wave following the QRS or as a small secondary R wave (R′). Also referred to as an Osborn wave, the J wave has been observed in the ECG of animals and humans for more than four decades, yet the mechanism underlying its manifestation is poorly understood. The present study investigates the cellular basis for the J wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle. Methods and Results A 12-lead ECG was initially recorded in vivo. After isolation and arterial perfusion of the right or left ventricular wedge, transmembrane action potentials were simultaneously recorded from epicardial, M region, and endocardial transmural sites with three floating microelectrodes. A transmural ECG was recorded concurrently. A J wave was observed at the R-ST junction of the ECG in 17 of 20 adult dogs, usually in leads II, III, aVR, and aVF and the mid to lateral precordial leads. The J wave...read more
Citations
More filters
Journal ArticleDOI
Differential diagnosis between early repolarization of athlete's heart and coved-type Brugada electrocardiogram.
Alessandro Zorzi,Loira Leoni,Fernando M. Di Paolo,Ilaria Rigato,Federico Migliore,Barbara Bauce,Antonio Pelliccia,Domenico Corrado +7 more
TL;DR: The STJ/ST₀ ratio is a highly accurate electrocardiographic parameter for differential diagnosis between anterior ER of the athlete and BS and may help in reducing the number of athletes who undergo expensive diagnostic workup or are unnecessarily disqualified from competition for changes that fall within the normal range of athlete's heart.
Journal ArticleDOI
Increased dispersion of repolarization time determined by monophasic action potentials in two patients with familial idiopathic ventricular fibrillation.
Kiyotaka Matsuo,Wataru Shimizu,Takashi Kurita,Kazuhiro Suyama,Naohiko Aihara,Shiro Kamakura,Katsuro Shimomura +6 more
TL;DR: The role of increased dispersion of repolarization in the genesis of torsades de pointes in patients with long QT syndrome is clarified and monophasic action potentials (MAPs) from two siblings with familial idiopathic VF are recorded.
Journal ArticleDOI
Menstrual cycle and ST height.
Susanne Endres,Kenneth A. Mayuga,Alessandro de Cristofaro,Taresh Taneja,Jeffrey J. Goldberger,Alan H. Kadish +5 more
TL;DR: This data indicates that the effect of sex hormones and menstrual cycle effects on ST height have not yet been clearly identified and are likely to be underestimated.
Journal ArticleDOI
J-Wave Syndromes Caused by Repolarization or Depolarization Mechanisms: A Debated Issue Among Experimental and Clinical Electrophysiologists
Martin Borggrefe,Rainer Schimpf +1 more
TL;DR: The J-wave deflection occurring at the QRS-ST junction (also known as Osborn waves) was first described in 1953 and is seen in many conditions such as hypothermia; hypercalcemia; brain injury; vasospastic angina; acute ischemia, especially in true posterior myocardial infarction with occlusion of
Journal ArticleDOI
Management of ventricular arrhythmias in suspected channelopathies.
TL;DR: The risk of ventricular arrhythmias associated with channelopathies including long QT syndrome, the evolving understanding of the mechanism of arrhythmia, and the mechanistic basis of therapies are presented along with a clinical approach to summarize the evidence pertaining to acute and long-term management.
References
More filters
Journal ArticleDOI
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
TL;DR: Common clinical and ECG features define a distinct syndrome in this group of patients with recurrent episodes of aborted sudden death unexplainable by currently known diseases, not explainable by electrolyte disturbances, ischemia or structural heart disease.
Journal ArticleDOI
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Charles Antzelevitch,Serge Sicouri,Silvio H. Litovsky,Anton Lukas,S C Krishnan,J. M. Di Diego,G. A. Gintant,Da-Wei Liu +7 more
TL;DR: In spite of important advances in cardiology in recent years, pharmacological control of cardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient basis using a trial and error approach tempered by good clinical judgment.
Journal ArticleDOI
Inward current channels activated by intracellular Ca in cultured cardiac cells.
TL;DR: Researchers report here studies on single channel currents recorded from heart muscle cells, in which they have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories.
Journal ArticleDOI
Characteristics of the Delayed Rectifier Current (IKr and IKs) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes A Weaker IKs Contributes to the Longer Action Potential of the M Cell
Da-Wei Liu,Charles Antzelevitch +1 more
TL;DR: The results suggest that the distinctive phase-3 repolarization features of M cells are due in part to a lesser contribution of IKs and that this distinction may also explain why M Cells are the main targets for agents that prolong APD in ventricular myocardium.
Journal ArticleDOI
Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts.
TL;DR: It is proposed that the parallel orientation of the muscle bundles in the epicardial border zone is an important cause of ventricular tachycardia because activation transverse to myocardial fibers is sufficiently slow to permit the occurrence of reentry.
Related Papers (5)
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
Sudden Cardiac Arrest Associated with Early Repolarization
Michel Haïssaguerre,Nicolas Derval,Frederic Sacher,Laurence Jesel,Isabel Deisenhofer,Luc De Roy,Jean-Luc Pasquié,Akihiko Nogami,Dominique Babuty,Sinikka Yli-Mäyry,Christian de Chillou,Patrice Scanu,Philippe Mabo,Seiichiro Matsuo,Vincent Probst,Solena Le Scouarnec,Pascal Defaye,Juerg Schlaepfer,Thomas Rostock,Dominique Lacroix,Dominique Lamaison,Thomas Lavergne,Yoshifusa Aizawa,Anders Englund,Frédéric Anselme,Mark D O'Neill,Mélèze Hocini,Kang-Teng Lim,Sébastien Knecht,George D. Veenhuyzen,Pierre Bordachar,Michel Chauvin,Pierre Jaïs,Gaelle Coureau,Geneviève Chêne,George Klein,Jacques Clémenty +36 more
Cellular Basis for the Brugada Syndrome and Other Mechanisms of Arrhythmogenesis Associated With ST-Segment Elevation
Gan-Xin Yan,Charles Antzelevitch +1 more