Journal ArticleDOI
Central kappa- and mu-opiate receptors mediate ACTH-release in rats.
TLDR
The data suggest that both mu- and kappa-opiate receptors are involved in the stimulation of ACTH release in rats, and the role of different opiate receptors in the control ofACTH release is elucidated.Abstract:
The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agonists and antagonists. The mu-opiate agonists, morphine and (D-Ala2,MePhe4,Gly5-ol)enkephalin, and the benzomorphan kappa-opiate agonists, MR 2034 and MRZ 2549, both stimulated ACTH release after central or peripheral injection. The effects of morphine, but not those of MR 2034, were blocked by a low dose of naloxone (50 ug/kg) and by the mu-receptor antagonist, beta-funaltrexamine. A 20 times higher dose of naloxone also blocked the effects of the kappa-agonist. Our data suggest that both mu- and kappa-opiate receptors are involved in the stimulation of ACTH release in rats.read more
Citations
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Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
TL;DR: A broad anatomical maps of the three opioid-receptor mRNAs in relation to their binding sites is provided, and issues of receptor transport, trafficking and pre- versus postsynaptic localization are discussed.
Journal ArticleDOI
Mu, Delta, and Kappa Opioid Receptor mRNA Expression in the Rat CNS: An In Situ Hybridization Study
Alfred Mansour,Charles A. Fox,Sharon Burke,Fan Meng,Robert C. Thompson,Huda Akil,Stanley J. Watson +6 more
TL;DR: The μ, δ, and κ opioid receptors are the three main types of opioid receptors round in the central nervous system (CNS) and periphery and are important in a number of physiological functions, including analgesia, respiration, and hormonal regulation.
Journal ArticleDOI
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
TL;DR: The hypothalamo-pituitary-adrenal axis (HPA) and the effects of corticotropin-releasing hormone (CRH) and vasopressin (VP) on anterior pituitary cells and factors regulating CRH neurosecrctory cell activity are studied.
Journal ArticleDOI
Dynorphin, stress, and depression
TL;DR: This review summarizes current data on how KOR systems contribute to the acute, delayed, and cumulative molecular and behavioral effects of stress and focuses on behavioral paradigms that provide insight on interactions between stress and KOR function within each of these temporal categories.
Journal ArticleDOI
Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS
TL;DR: Polyclonal antibodies were generated to the C terminal 63 amino acids of the cloned mu receptor to examine the distribution of the mu receptor-like protein with immunohistochemical techniques, and the anatomical and functional implications of these findings are discussed.
References
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Journal ArticleDOI
A classification of opiate receptors that mediate antinociception in animals.
TL;DR: It is concluded that both μ‐ and κ‐opiate receptors mediate antinociception in animals and that the interactions of analgesic drugs with these receptors may be classified in terms of their antinOCiceptive activities against qualitatively different nociceptive stimuli.
Journal Article
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