Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.
Alejandra Daruich,Alexandre Matet,Ali Dirani,Elodie Bousquet,Min Zhao,Nicolette Farman,Frederic Jaisser,Francine Behar-Cohen +7 more
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TLDR
The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options, and the novel mineralocorticoid pathway hypothesis.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2015-09-01 and is currently open access. It has received 690 citations till now. The article focuses on the topics: Animal data & Mineralocorticoid receptor.read more
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Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes
R. Margolis,Richard F. Spaide +1 more
TL;DR: In this paper, the authors measured the macular choroid thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and age.
Journal ArticleDOI
Mechanisms of macular edema: Beyond the surface.
Alejandra Daruich,Alexandre Matet,Alexandre Moulin,Laura Kowalczuk,Michael Nicolas,Alexandre Sellam,Pierre-Raphaël Rothschild,Samy Omri,Emmanuelle Gelize,Laurent Jonet,Kimberley Delaunay,Yvonne de Kozak,Marianne Berdugo,Min Zhao,Patricia Crisanti,Francine Behar-Cohen,Francine Behar-Cohen +16 more
TL;DR: This comprehensive review on the current understanding of macular edema and its mechanisms opens perspectives to identify new preventive and therapeutic strategies for this sight-threatening condition.
Journal ArticleDOI
Wide-field choroidal thickness profile in healthy eyes.
Mohammed Abdul Rasheed,Sumit Randhir Singh,Alessandro Invernizzi,Carlo Cagini,Abhilash Goud,Niroj Kumar Sahoo,Mariano Cozzi,Marco Lupidi,Jay Chhablani +8 more
TL;DR: Choroidal thickness and large choroidal vessel thickness of 20 eyes in horizontal and vertical meridians using WF-OCT are evaluated using wide field optical coherence tomography to find that CT and LCVT are highest at the macular area with reduction towards the periphery.
Journal ArticleDOI
Emerging Roles of the Mineralocorticoid Receptor in Pathology: Toward New Paradigms in Clinical Pharmacology
F. Jaisser,N. Farman +1 more
TL;DR: Excess mineralocorticoid signaling now appears deleterious in the progression of pathologies that may lead to end-stage organ failure and could therefore benefit from the repositioning of pharmacological MR antagonists.
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Central serous chorioretinopathy: Towards an evidence-based treatment guideline
Thomas J. van Rijssen,Elon H. C. van Dijk,Suzanne Yzer,Kyoko Ohno-Matsui,Jan E.E. Keunen,Reinier O. Schlingemann,Sobha Sivaprasad,Giuseppe Querques,Susan M. Downes,Sascha Fauser,Carel B. Hoyng,Felice Cardillo Piccolino,Jay Chhablani,Timothy Y Y Lai,Andrew J. Lotery,Michael Larsen,Frank G. Holz,K. Bailey Freund,Lawrence A. Yannuzzi,Camiel J. F. Boon,Camiel J. F. Boon +20 more
TL;DR: A comprehensive overview of the current rationale and evidence with respect to the variety of interventions available for treating central serous chorioretinopathy, including pharmacology, laser treatment, and photodynamic therapy is provided.
References
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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
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Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction
Bertram Pitt,Willem J. Remme,Faiez Zannad,James D. Neaton,Felipe Martinez,Barbara Roniker,Richard Bittman,Steve Hurley,Jay H. Kleiman,Marjorie Gatlin +9 more
TL;DR: The addition of eplerenone to optimal medical therapy reduces morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure.
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A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes.
Ron Margolis,Richard F. Spaide +1 more
TL;DR: The decrease in the thickness of the choroid may play a role in the pathophysiologic features of various age-related ocular conditions and seems to vary topographically within the posterior pole.
Journal Article
Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes
R. Margolis,Richard F. Spaide +1 more
TL;DR: In this paper, the authors measured the macular choroid thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and age.