Journal ArticleDOI
Centrally active N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine)
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Measurements of the pharmacological activity of a series of analogs with substituents on the nitrogen atom indicated that the central activity decreased with the increasing bulk of the N-substituent.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1980-02-01. It has received 124 citations till now. The article focuses on the topics: Sodium cyanoborohydride & Alkoxy group.read more
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Subjective reports of the effects of MDMA in a clinical setting.
George R. Greer,Requa Tolbert +1 more
TL;DR: The psychological effects of MDMA were first relaboratory of Alexander Shulgin, Ph.D., who had colported in 1978 by Shulkin and Nichols and was no synthesis, and was synthesized in the actual or possible pregnancy.
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In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
TL;DR: Comparisons of the stereoisomers of methylenedioxymethamphetamine and its n-desmethyl analog, methylenedioxyamphetamine, indicated two phases of serotonin depletion similar to those reported for p-chloroamphetamine, and the (+)-enantiomer of both drugs to be the more potent releasing agent.
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3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans
TL;DR: Improved recognition of MDMA-related syndromes is hoped to provide insight into the function of serotonin in the human brain, in health as well as disease.
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Laboratory and field experiments used to identify Canis lupus var. familiaris active odor signature chemicals from drugs, explosives, and humans
Norma Lorenzo,TianLang Wan,Ross J. Harper,Ya-Li Hsu,Michael Chow,Stefan Rose,Kenneth G. Furton +6 more
TL;DR: SPME–GC/MS has been demonstrated to have a unique capability for the extraction of volatiles from the headspace of forensic specimens including drugs and explosives and shows great potential to aid in the investigation and understanding of the complicated process of canine odor detection.
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The background and chemistry of MDMA.
TL;DR: Up to 1972, MDMA was entered with the phenethylamine exists in the literature representing the results of laboraname, and since then the heterocyclic term benzodioxole-5i tory studies and scientific experimentation with ethanamine has been the root name.
References
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Cyanohydridoborate anion as a selective reducing agent
TL;DR: The use of modified boron hydrides as selective reducing agents for organic functional g roups has been studied extensively as discussed by the authors, with a focus on reducing a wide variety of organic functional groups with remarkable selectivity.
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Structure–Activity Relationships of One-Ring Psychotomimetics
TL;DR: Human dose-response relationships for psychotomimetic phenethylamines : an isopropylamine side chain and triple methoxy substitution provide optimum activity.
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Relationship of the structure of mescaline and seven analogs to toxicity and behavior in five species of laboratory animals.
Harold F. Hardman,Harold F. Hardman,Coryce O. Haavik,Coryce O. Haavik,Maurice H. Seevers,Maurice H. Seevers +5 more
TL;DR: A comparison of the observable signs of drug action in the dog and monkey shows the dog to be the preferred species for evaluating the effects of these agents.
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Psychotomimetic amphetamines: Methoxy 3,4-dialkoxyamphetamines
TL;DR: Le déplacement d'un méthoxyl à une positionortho- de la chaîne aliphatique a montré, dans trois cas une amplification multiple quant à l'efficacité humaine.