Open Access
Ceramic microfluidic microsystems for high temperature and high pressure applications.
TLDR
In this article, an integrated microfluidic lyser using LTCC technology has been fabricated, which enables the use of aqueous buffers at high temperatures without boiling by using a pressurized system.Abstract:
As an alternative material to glass, silicon, and plastics, Low Temperature Cofired Ceramic (LTCC) substrate technology is becoming increasingly important for enabling microfluidic microsystems and devices for integrated chemical and biological analysis. LTCC's simple fabrication method and unique ability to withstand high temperatures and high pressures make it well-suited for applications not possible with traditional materials. As part of Sandia's initiative to develop an automated sample preparation system for the μChemlab™ bioagent detector, an integrated microfluidic lyser using LTCC technology has been fabricated, which enables the use of aqueous buffers at high temperatures without boiling by using a pressurized system. Thermal lysing of bacterial spores in a flow-through microfluidic device at temperatures as high as 220°C and pressures up to 10.3 MPa (1,500 psi) represents a new method for solubilizing spore proteins for identification and analysis, eliminating the reliance on harsh chemical red...read more
Citations
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Journal Article
LTCC microreactor for urea determination in biological fluids.
TL;DR: In this paper, an enzymatic microreactor with integrated heater and a temperature sensor was used to measure urea concentration with high output signal (ca. 2.5 pH units) and large scale.
Journal ArticleDOI
Microfluidic techniques for enhancing biofuel and biorefinery industry based on microalgae
TL;DR: Comments toward future developments (high-pressure/-temperature process; solvent-resistant devices; omics analysis, including genome/epigenome, proteome, and metabolome; biofilm reactors) of microfluidic techniques for microalgae applications are provided.
Journal ArticleDOI
Fabrication of Precise Fluidic Structures in LTCC
Fred Barlow,Jared Wood,Aicha Elshabini,Edward F. Stephens,Ryan Feeler,Greg Kemner,Jeremy Junghans +6 more
TL;DR: In this article, the authors describe the fabrication process used to create the precise channel and jet structures used in these LTCC-based coolers, as well as some of the challenges associated with these processes, including the erosion of the copper coolers by the coolant, a requirement for the use of deionized water within the system, and a significant CTE mismatch between the diode bar and the metal cooler.
Journal ArticleDOI
Novel LTCC-potentiometric microfluidic device for biparametric analysis of organic compounds carrying plastic antibodies as ionophores: application to sulfamethoxazole and trimethoprim.
Sofia A. A. Almeida,E. Arasa,Mar Puyol,Cynthia S. Martínez-Cisneros,Julián Alonso-Chamarro,Maria C. B. S. M. Montenegro,M.G.F. Sales +6 more
TL;DR: A low-temperature co-fired ceramics microfluidic potentiometric device was developed for the first time for an organic compound: sulfamethoxazole (SMX) and successfully applied to single and simultaneous determination of SMX and TMP in aquaculture waters.
Proceedings Article
LTCC in microelectronics, microsystems, and sensors
Kenneth A. Peterson,Richard T. Knudson,Ernest J. Garcia,Kamlesh D. Patel,Murat Okandan,Clifford K. Ho,Conrad D. James,Steven B. Rohde,Brandon Rohrer,F. Smith,L.R. Zawicki,Brian D. Wroblewski +11 more
TL;DR: In this article, the authors discuss accomplishments at Sandia in RF, microfluidics, gas handling, microsystems, and sensor applications, highlighting areas such as radar MCMs, biological micro systems, smart channels, and new sensor geometries including rolled ceramic tubular substrates.
References
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Journal ArticleDOI
LTCC microreactor for urea determination in biological fluids
TL;DR: In this paper, an enzymatic microreactor with integrated heater and a temperature sensor was used to measure urea concentration with high output signal (ca. 2.5 pH units) and large scale.
Journal ArticleDOI
Microfluidic techniques for enhancing biofuel and biorefinery industry based on microalgae
TL;DR: Comments toward future developments (high-pressure/-temperature process; solvent-resistant devices; omics analysis, including genome/epigenome, proteome, and metabolome; biofilm reactors) of microfluidic techniques for microalgae applications are provided.
Journal ArticleDOI
Fabrication of Precise Fluidic Structures in LTCC
Fred Barlow,Jared Wood,Aicha Elshabini,Edward F. Stephens,Ryan Feeler,Greg Kemner,Jeremy Junghans +6 more
TL;DR: In this article, the authors describe the fabrication process used to create the precise channel and jet structures used in these LTCC-based coolers, as well as some of the challenges associated with these processes, including the erosion of the copper coolers by the coolant, a requirement for the use of deionized water within the system, and a significant CTE mismatch between the diode bar and the metal cooler.
Journal ArticleDOI
Novel LTCC-potentiometric microfluidic device for biparametric analysis of organic compounds carrying plastic antibodies as ionophores: application to sulfamethoxazole and trimethoprim.
Sofia A. A. Almeida,E. Arasa,Mar Puyol,Cynthia S. Martínez-Cisneros,Julián Alonso-Chamarro,Maria C. B. S. M. Montenegro,M.G.F. Sales +6 more
TL;DR: A low-temperature co-fired ceramics microfluidic potentiometric device was developed for the first time for an organic compound: sulfamethoxazole (SMX) and successfully applied to single and simultaneous determination of SMX and TMP in aquaculture waters.
Proceedings Article
LTCC in microelectronics, microsystems, and sensors
Kenneth A. Peterson,Richard T. Knudson,Ernest J. Garcia,Kamlesh D. Patel,Murat Okandan,Clifford K. Ho,Conrad D. James,Steven B. Rohde,Brandon Rohrer,F. Smith,L.R. Zawicki,Brian D. Wroblewski +11 more
TL;DR: In this article, the authors discuss accomplishments at Sandia in RF, microfluidics, gas handling, microsystems, and sensor applications, highlighting areas such as radar MCMs, biological micro systems, smart channels, and new sensor geometries including rolled ceramic tubular substrates.