Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: Interim outcomes from the GREAT2DO Trial.
Yorgi Mavros,Shelley Kay,Kylie A. Anderberg,Micahel K Baker,Micahel K Baker,Yi Wang,Yi Wang,Renru Zhao,Jacinda Meiklejohn,Mike Climstein,Anthony J O'Sullivan,Nathan De Vos,Bernhard T. Baune,Steven N. Blair,David Simar,Kieron Rooney,Nalin Singh,Maria A. Fiatarone Singh +17 more
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TLDR
Improvements in metabolic health in older adults with type 2 diabetes were mediated through improvements in body composition only if they were achieved through high-intensity PRT.Citations
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Hippocampal insulin resistance and cognitive dysfunction
TL;DR: Intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD are discussed.
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Update on the effects of physical activity on insulin sensitivity in humans.
Stephen R. Bird,John A. Hawley +1 more
TL;DR: Evidence is provided that regular PA reduces the risk of insulin resistance, metabolic syndrome and type 2 diabetes, and SI improves when individuals comply with exercise and/or PA guidelines, although these findings are not unanimous.
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Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis
TL;DR: Insulin appears to have a permissive role in MPS in the presence of elevated AAs, and plays a clear role in reducing MPB independent of AA availability, and demonstrates the complex role of insulin in regulating skeletal muscle metabolism.
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International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
Mikel Izquierdo,Mikel Izquierdo,Mikel Izquierdo,Reshma A. Merchant,John E. Morley,Stefan D. Anker,Ivan Aprahamian,Hidenori Arai,Mylène Aubertin-Leheudre,Roberto Bernabei,Eduardo Lusa Cadore,M. Cesari,Lizhu Chen,P. de Souto Barreto,Gustavo Duque,Luigi Ferrucci,Roger A. Fielding,Antonio García-Hermoso,Antonio García-Hermoso,Luis Miguel Gutiérrez-Robledo,Stephen D. R. Harridge,Ben Kirk,S. B. Kritchevsky,Francesco Landi,Norman R. Lazarus,Finbarr C. Martin,Emanuele Marzetti,Marco Pahor,Robinson Ramírez-Vélez,Robinson Ramírez-Vélez,Leocadio Rodríguez-Mañas,Yves Rolland,Jorge G. Ruiz,Olga Theou,Dennis T. Villareal,Debra L. Waters,C. Won Won,Jean Woo,Bruno Vellas,M. Fiatarone Singh +39 more
TL;DR: In this paper, the authors provide evidence-based rationale for using exercise and physical activity (PA) for health promotion and disease prevention and treatment in older adults, and discuss the specific modalities and doses that have been studied in randomised controlled trials for their effectiveness in attenuating physiological changes of ageing, disease prevention, and/or improvement of older adults with chronic disease and disability.
Journal ArticleDOI
Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases
Prue Cormie,Robert U. Newton,Nigel Spry,Nigel Spry,Nigel Spry,David Joseph,David Joseph,David Joseph,Dennis R. Taaffe,Dennis R. Taaffe,Daniel A. Galvão +10 more
TL;DR: Initial evidence involving a small sample size suggests that appropriately designed and supervised resistance exercise may be safe and well tolerated by prostate cancer patients with bone metastatic disease and can lead to improvements in physical function, physical activity levels and lean mass.
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G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
TL;DR: G*Power 3 provides improved effect size calculators and graphic options, supports both distribution-based and design-based input modes, and offers all types of power analyses in which users might be interested.
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Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.
Enzo Bonora,Giovanni Targher,Maria Alberiche,Riccardo C. Bonadonna,F. Saggiani,M. Zenere,T Monauni,Michele Muggeo +7 more
TL;DR: The HOMA can be reliably used in large-scale or epidemiological studies in which only a fasting blood sample is available to assess insulin sensitivity and there is good agreement between the two methods in the categorization of subjects according to insulin sensitivity.