Changing demography and the challenge of dementia in India.
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In this article, the authors reviewed the literature concerning dementia epidemiology and risk factors in the Indian population and discussed the future work that needs to be performed to put in place public health interventions to mitigate the burden of dementia.Abstract:
In India, increasing lifespan and decreasing fertility rates have resulted in a growing number of older persons. By 2050, people over 60 years of age are predicted to constitute 19.1% of the total population. This ageing of the population is expected to be accompanied by a dramatic increase in the prevalence of dementia. The aetiopathogenesis of dementia has been the subject of a number of prospective longitudinal studies in North America and Europe; however, the findings from these studies cannot simply be translated to the Indian population. The population of India is extremely diverse in terms of socio-economic, cultural, linguistic, geographical, lifestyle-related and genetic factors. Indeed, preliminary data from recently initiated longitudinal studies in India indicate that the prevalence of vascular and metabolic risk factors, as well as white matter hyperintensities, differs between urban and rural cohorts. More information on the complex role of vascular risk factors, gender and genetic influences on dementia prevalence and progression in Indian populations is urgently needed. Low-cost, culturally appropriate and scalable interventions need to be developed expeditiously and implemented through public health measures to reduce the growing burden of dementia. Here, we review the literature concerning dementia epidemiology and risk factors in the Indian population and discuss the future work that needs to be performed to put in place public health interventions to mitigate the burden of dementia.read more
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References
More filters
Journal ArticleDOI
An integrated map of genetic variation from 1,092 human genomes
Gonçalo R. Abecasis,Adam Auton,Lisa D. Brooks,Mark A. DePristo,Richard Durbin,Robert E. Handsaker,Robert E. Handsaker,Hyun Min Kang,Gabor T. Marth,Gil McVean +9 more
TL;DR: It is shown that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites.
Journal ArticleDOI
Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
TL;DR: The findings challenge the single-disease framework by which most health care, medical research, and medical education is configured, and a complementary strategy is needed, supporting generalist clinicians to provide personalised, comprehensive continuity of care, especially in socioeconomically deprived areas.
Journal ArticleDOI
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Sudha Seshadri,Alexa S. Beiser,Jacob Selhub,Paul F. Jacques,Irwin H. Rosenberg,Ralph B. D'Agostino,Peter W.F. Wilson,Philip A. Wolf +7 more
TL;DR: Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased.
Journal ArticleDOI
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
Dena Ettehad,Connor A. Emdin,Amit Kiran,Simon G Anderson,Simon G Anderson,Thomas Callender,Thomas Callender,Jonathan Emberson,John Chalmers,Anthony Rodgers,Kazem Rahimi +10 more
TL;DR: In this article, a systematic review and meta-analysis of large-scale blood pressure lowering trials, published between Jan 1, 1966, and July 7, 2015, was performed.
Journal ArticleDOI
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu,Tiia Ngandu,Jenni Lehtisalo,Alina Solomon,Alina Solomon,Esko Levälahti,Satu Ahtiluoto,Riitta Antikainen,Lars Bäckman,Tuomo Hänninen,Antti Jula,Tiina Laatikainen,Tiina Laatikainen,Jaana Lindström,Francesca Mangialasche,Teemu Paajanen,Satu Pajala,Markku Peltonen,Rainer Rauramaa,Anna Stigsdotter-Neely,Timo E. Strandberg,Timo E. Strandberg,Jaakko Tuomilehto,Hilkka Soininen,Miia Kivipelto +24 more
TL;DR: In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, the authors aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.