Alina Solomon

TL;DR: In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a proof-of-concept randomised controlled trial, the authors aimed to assess a multidomain approach to prevent cognitive decline in at-risk elderly people from the general population.

TL;DR: It is acknowledged that a single cure for Alzheimer's disease is unlikely to be found and that the approach to drug development for this disorder needs to be reconsidered, but several promising randomised controlled trials are ongoing and increased collaboration between pharmaceutical companies, basic researchers, and clinical researchers has the potential to bring us closer to developing an optimum pharmaceutical approach.

TL;DR: Investigating midlife cholesterol in relation to Alzheimer’s disease and vascular dementia in a large multiethnic cohort of women and men found that moderately elevated cholesterol increased dementia risk.

TL;DR: Elderly patients with diabetes develop more extensive vascular pathology, which alone or together with AD-type pathology (particularly in APOE ε4 carriers) results in increased dementia risk.

TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.